Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, CH-8092, Zurich, Switzerland.
Institute for Chemical and Bioengineering, ETH Zurich, Tannenstrasse 3, CH-8092, Zurich, Switzerland.
Adv Mater. 2019 Jul;31(27):e1901592. doi: 10.1002/adma.201901592. Epub 2019 May 6.
Motile metal-organic frameworks (MOFs) are potential candidates to serve as small-scale robotic platforms for applications in environmental remediation, targeted drug delivery, or nanosurgery. Here, magnetic helical microstructures coated with a kind of zinc-based MOF, zeolitic imidazole framework-8 (ZIF-8), with biocompatibility characteristics and pH-responsive features, are successfully fabricated. Moreover, it is shown that this highly integrated multifunctional device can swim along predesigned tracks under the control of weak rotational magnetic fields. The proposed systems can achieve single-cell targeting in a cell culture media and a controlled delivery of cargo payloads inside a complex microfluidic channel network. This new approach toward the fabrication of integrated multifunctional systems will open new avenues in soft microrobotics beyond current applications.
动力金属-有机骨架（MOFs）是一种潜在的候选材料，可以作为小型机器人平台，用于环境修复、靶向药物输送或纳米手术等应用。在这里，我们成功制备了具有生物相容性和 pH 响应特性的磁性螺旋微结构，其表面涂覆了一种锌基 MOF，沸石咪唑骨架-8（ZIF-8）。此外，研究表明，这种高度集成的多功能设备可以在弱旋转磁场的控制下沿着预定的轨迹游动。所提出的系统可以在细胞培养介质中实现单细胞靶向，并在复杂的微流控通道网络中控制货物有效负载的释放。这种制造集成多功能系统的新方法将为软机器人技术开辟新的途径，超越当前的应用。
