Zeka Keti, Ruparelia Ketan, Arroo Randolph R J, Budriesi Roberta, Micucci Matteo
Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK.
Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Diseases. 2017 Sep 5;5(3):19. doi: 10.3390/diseases5030019.
The occurrence of atherosclerosis and diabetes is expanding rapidly worldwide. These two metabolic disorders often co-occur, and are part of what is often referred to as the metabolic syndrome. In order to determine future therapies, we propose that molecular mechanisms should be investigated. Once the aetiology of the metabolic syndrome is clear, a nutritional intervention should be assessed. Here we focus on the protective effects of some dietary flavonoids, and their metabolites. Further studies may also pave the way for development of novel drug candidates.
动脉粥样硬化和糖尿病在全球范围内的发病率正在迅速上升。这两种代谢紊乱常常同时出现，并且是通常所说的代谢综合征的一部分。为了确定未来的治疗方法，我们建议应该研究分子机制。一旦代谢综合征的病因明确，就应该评估营养干预措施。在这里，我们重点关注一些膳食黄酮类化合物及其代谢产物的保护作用。进一步的研究也可能为新型候选药物的开发铺平道路。
