1Department of Clinical and Experimental Medicine,University of Pisa,Pisa,Italy.
2Department of Pharmaceutical and Pharmacological Sciences,University of Padova,Padova,Italy.
Nutr Res Rev. 2018 Dec;31(2):239-247. doi: 10.1017/S0954422418000082. Epub 2018 Jun 6.
Obesity represents one of major health problems strongly linked to other co-morbidities, such as type 2 diabetes, CVD, gastrointestinal disorders and cognitive impairment. In this context, nutritional stress, such as an excess of fat intake, promotes a systemic oxidative stress, characterised by hyperproduction of reactive oxygen species, leading to cellular alterations that include impaired energy metabolism, altered cell signalling and cell cycle control, impaired cell transport mechanisms and overall dysfunctional biological activity. Flavonoids, dietary components of plant foods, are endowed with a wide spectrum of biological activities, including antioxidant activity, and have been proposed to reduce the risk of major chronic diseases. The present review intends to highlight and critically discuss the current scientific evidence on the possible effects of flavonoids in counteracting obesity and related co-morbidities (i.e. type 2 diabetes mellitus, CVD, gastrointestinal disorders and cognitive impairment) through a decrease in oxidative stress and related inflammatory conditions.
肥胖是一个主要的健康问题，与其他合并症密切相关，如 2 型糖尿病、心血管疾病、胃肠道疾病和认知障碍。在这种情况下，营养压力，如脂肪摄入过多，会导致全身性氧化应激，表现为活性氧的过度产生，导致细胞改变，包括能量代谢受损、细胞信号转导和细胞周期控制改变、细胞转运机制受损以及整体生物功能障碍。类黄酮是植物性食物的成分，具有广泛的生物活性，包括抗氧化活性，并且已经被提议降低主要慢性疾病的风险。本综述旨在通过降低氧化应激和相关炎症状态，强调和批判性地讨论类黄酮在对抗肥胖及其相关合并症（即 2 型糖尿病、心血管疾病、胃肠道疾病和认知障碍）方面的可能作用的现有科学证据。
