年龄和神经炎症在镰状细胞病认知缺陷机制中的作用。
Role of age and neuroinflammation in the mechanism of cognitive deficits in sickle cell disease.
机构信息
Neuroscience Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA 30322, USA.
Atlanta Sickle Cell Disease Consortium, Emory University, Atlanta, GA 30322, USA.
出版信息
Exp Biol Med (Maywood). 2021 Jan;246(1):106-120. doi: 10.1177/1535370220958011. Epub 2020 Sep 22.
Abstract
This study provides crucial information that could be helpful in the development of new or repurposing of existing therapies for the treatment of cognitive deficit in individuals with sickle cell disease (SCD). Its impact is in demonstrating for the first time that neuroinflammation and along with abnormal neuroplasticity are among the underlying mechanism of cognitive and behavioral deficits in SCD and that drugs such as minocycline which targets these pathophysiological mechanisms could be repurposed for the treatment of this life altering complication of SCD.
摘要
这项研究提供了重要信息，有助于开发新的治疗方法或重新利用现有的治疗方法，以治疗镰状细胞病（SCD）患者的认知缺陷。其影响在于首次证明神经炎症和异常神经可塑性是 SCD 认知和行为缺陷的潜在机制之一，而米诺环素等针对这些病理生理机制的药物可以被重新用于治疗 SCD 这种改变生活的并发症。
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