Union Department of Infection Disease, Wuhan University Renmin Hospital, Wuhan, 430060, China.
Department of Neurology, Wuhan University Renmin Hospital, Wuhan, 430060, China.
BMC Infect Dis. 2020 Sep 22;20(1):695. doi: 10.1186/s12879-020-05423-7.
With the widespread outbreak of novel coronavirus diseases 2019(COVID-19), more and more death cases were reported, however, limited data are available for the patients who died. We aimed to explore the clinical characteristics of deaths with COVID-19 pneumonia.
We abstracted and analyzed epidemiological, demographic, clinical, and laboratory data from 83 death cases with COVID-19 pneumonia in East Hospital of Wuhan University Renmin Hospital, between January 26, 2020, and February 28, 2020.
Of the 83 deaths, none was the medical staff. The mean age was 71.8 years (SD 13.2; range, 34-97 years) and 53(63.9%) were male. The median from onset to admission was 10 days (IQR 7-14: range, 2-43 days), to death was 17 days (IQR 14-21: range, 6-54 days). Most deaths (66[80%]) had underlying comorbid diseases, the most of which was hypertension [47(57%)]. The main initial symptoms of these 83 deaths were shortness of breath(98.8%), fever(94%), and myalgia or fatigue(90.4%). Laboratory analyses showed the lymphocytopenia in 69(83%) deaths, hypoalbuminemia in 77(93%) deaths, the elevation of lactate dehydrogenase in 79(95%) deaths, procalcitonin in 69(83%) deaths and C-reactive protein in 79(95%) deaths. All 83 patients received antiviral treatment, 81(97.6%) deaths received antibiotic therapy, 54(65.1%) deaths received glucocorticoid therapy, and 20(24.1%) patients received invasive mechanical ventilation.
Most of the deaths with COVID-19 pneumonia were elderly patients with underlying comorbid diseases, especially those over 70 years of age. The time of death after the onset of the disease was mostly 15-21 days. More care should be given to the elderly in further prevention and control strategies of COVID-19.
随着 2019 年新型冠状病毒病（COVID-19）的广泛爆发，报告的死亡病例越来越多，但可用于死亡患者的资料有限。我们旨在探讨 COVID-19 肺炎死亡患者的临床特征。
我们从 2020 年 1 月 26 日至 2020 年 2 月 28 日期间，从武汉大学人民医院东院的 83 例 COVID-19 肺炎死亡病例中提取和分析了流行病学、人口统计学、临床和实验室数据。
在 83 例死亡病例中，没有医务人员。平均年龄为 71.8 岁（标准差 13.2；范围，34-97 岁），53 例（63.9%）为男性。从发病到入院的中位数为 10 天（IQR 7-14：范围，2-43 天），到死亡的中位数为 17 天（IQR 14-21：范围，6-54 天）。大多数死亡病例（66[80%]）有合并症，其中最常见的是高血压[47（57%）]。这些 83 例死亡的主要初始症状是呼吸急促（98.8%）、发热（94%）和肌痛或疲劳（90.4%）。实验室分析显示，69（83%）例死亡存在淋巴细胞减少症，77（93%）例死亡存在低白蛋白血症，79（95%）例死亡存在乳酸脱氢酶升高，69（83%）例死亡存在降钙素原升高，79（95%）例死亡存在 C-反应蛋白升高。所有 83 例患者均接受了抗病毒治疗，81（97.6%）例死亡患者接受了抗生素治疗，54（65.1%）例死亡患者接受了糖皮质激素治疗，20（24.1%）例患者接受了有创机械通气。
COVID-19 肺炎死亡患者大多为有合并症的老年患者，尤其是 70 岁以上的患者。从发病到死亡的时间大多为 15-21 天。在 COVID-19 的进一步防控策略中，应更加关注老年人。
