Collaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, 6027, Australia.
Biological and Health Psychology Department, School of Psychology, Universidad Autonoma de Madrid, 28049, Madrid, Spain.
Alzheimers Res Ther. 2020 Sep 22;12(1):113. doi: 10.1186/s13195-020-00681-8.
Electrophysiological studies show that reductions in power within the alpha band are associated with the Alzheimer's disease (AD) continuum. Physical activity (PA) is a protective factor that has proved to reduce AD risk and pathological brain burden. Previous research has confirmed that exercise increases power in the alpha range. However, little is known regarding whether other non-modifiable risk factors for AD, such as increased age or APOE ε4 carriage, alter the association between PA and power in the alpha band.
The relationship between PA and alpha band power was examined in a sample of 113 healthy adults using magnetoencephalography. Additionally, we explored whether ε4 carriage and age modulate this association. The correlations between alpha power and gray matter volumes and cognition were also investigated.
We detected a parieto-occipital cluster in which PA positively correlated with alpha power. The association between PA and alpha power remained following stratification of the cohort by genotype. Younger and older adults were investigated separately, and only younger adults exhibited a positive relationship between PA and alpha power. Interestingly, when four groups were created based on age (younger-older adult) and APOE (E3/E3-E3/E4), only younger E3/E3 (least predicted risk) and older E3/E4 (greatest predicted risk) had associations between greater alpha power and higher PA. Among older E3/E4, greater alpha power in these regions was associated with improved memory and preserved brain structure.
PA could protect against the slowing of brain activity that characterizes the AD continuum, where it is of benefit for all individuals, especially E3/E4 older adults.
电生理研究表明，α 频段的功率降低与阿尔茨海默病（AD）连续体有关。身体活动（PA）是一种保护因素，已被证明可降低 AD 风险和病理性脑负担。先前的研究已经证实，运动可以增加α 频段的功率。然而，对于 AD 的其他不可改变的风险因素，如年龄增长或 APOE ε4 携带，是否会改变 PA 与α 频段功率之间的关联，知之甚少。
本研究使用脑磁图检查了 113 名健康成年人样本中 PA 与α 频段功率之间的关系。此外，我们还探讨了 ε4 携带和年龄是否调节这种关联。还研究了α 功率与灰质体积和认知之间的相关性。
我们在顶枕部发现了一个 cluster，PA 与α 功率呈正相关。在按基因型分层队列后，PA 与α 功率之间的关联仍然存在。分别对年轻和年长的成年人进行了调查，只有年轻的成年人表现出 PA 与α 功率之间的正相关关系。有趣的是，当根据年龄（年轻-年长的成年人）和 APOE（E3/E3-E3/E4）将四个组创建时，只有年轻的 E3/E3（预测风险最低）和年长的 E3/E4（预测风险最大）与更大的α 功率和更高的 PA 之间存在关联。在年长的 E3/E4 中，这些区域中更大的α 功率与记忆改善和大脑结构保存相关。
PA 可以防止 AD 连续体中特征性的大脑活动减慢，这对所有人都有好处，尤其是 E3/E4 年长的成年人。
