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八十岁老人初次及翻修全膝关节置换术后的中期生存情况令人满意:一项当代单中心回顾性研究

Mid-term lifetime survivals of octogenarians following primary and revision total knee arthroplasties were satisfactory: a retrospective single center study in contemporary period.

作者信息

Song Sang Jun, Kim Kang Il, Bae Dae Kyung, Park Cheol Hee

机构信息

Department of Orthopaedic Surgery, College of Medicine, Kyung Hee University, Seoul, South Korea.

Department of Orthopaedic Surgery, Seoul Sacred Heart General Hospital, Seoul, South Korea.

出版信息

Knee Surg Relat Res. 2020 Sep 22;32(1):50. doi: 10.1186/s43019-020-00069-w.

Abstract

BACKGROUND

As life expectancy increases, the number of octogenarians requiring primary and revision total knee arthroplasty (TKA) is increasing. Recently, primary TKA has become a common treatment option in octogenarians. However, surgeons may still be hesitant about performing revision TKA on octogenarians because of concern about risk and cost benefit. The purpose of this study was to investigate clinical outcomes, postoperative complications, and mid-term lifetime survival in octogenarians after primary and revision TKA.

MATERIALS AND METHODS

We retrospectively reviewed 231 primary TKAs and 41 revision TKAs performed on octogenarians between 2000 and 2016. The mean age of patients undergoing primary TKA was 81.9 years and that of patients undergoing revision TKA was 82.3 years (p = 0.310). The age-adjusted Charlson comorbidity index was higher in revision TKA (4.4 vs. 4.8, p = 0.003). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and range of motion (ROM) were evaluated. The incidence of postoperative complications (TKA-related, specific or systemic) and lifetime survival rate (endpoint death determined by telephone or mail communication with patient or family) were investigated.

RESULTS

The WOMAC and ROM improved significantly after primary and revision TKA, although postoperative results were worse in the revision group (33.1 vs. 47.2; 128.9° vs. 113.6°; p < 0.001, respectively). There were no cases of aseptic or septic component failure in either group. One case of periprosthetic fracture was observed in the revision group (0% vs. 2.4%, p = 0.151), and three cases of deep vein thrombosis (DVT)/pulmonary thromboembolism (PTE) (one case of DVT and two cases of PTE) were observed in the primary group (1.3% vs. 0%, p = 1.000). The most common systemic complication in both groups was delirium (7.4% vs. 14.6%, p = 0.131). There were no differences between the two groups in the other systemic complication rates. The 5-year and 10-year lifetime survival rates were 87.2% and 62.9%, respectively, in primary TKA and 82.1% and 42.2%, respectively, in revision TKA (p = 0.017).

CONCLUSIONS

Both primary and revision TKA are viable options for octogenarians, based on the satisfactory clinical outcomes, TKA-related complication rates, and mid-term lifetime survival. Delirium needs to be managed appropriately as the most common systemic complication in both primary and revision TKA in octogenarians.

LEVEL OF EVIDENCE

IV.

摘要

背景

随着预期寿命的增加,需要初次和翻修全膝关节置换术(TKA)的八旬老人数量正在增加。最近,初次TKA已成为八旬老人常见的治疗选择。然而,由于担心风险和成本效益,外科医生在为八旬老人进行翻修TKA时可能仍会犹豫不决。本研究的目的是调查初次和翻修TKA术后八旬老人的临床结果、术后并发症和中期生存情况。

材料与方法

我们回顾性分析了2000年至2016年间对八旬老人进行的231例初次TKA和41例翻修TKA。接受初次TKA患者的平均年龄为81.9岁,接受翻修TKA患者的平均年龄为82.3岁(p = 0.310)。翻修TKA的年龄调整Charlson合并症指数更高(4.4对4.8,p = 0.003)。评估了西安大略和麦克马斯特大学骨关节炎指数(WOMAC)和活动范围(ROM)。调查了术后并发症(与TKA相关、特定或全身性)的发生率和生存率(通过与患者或家属电话或邮件沟通确定的终点死亡)。

结果

初次和翻修TKA后WOMAC和ROM均有显著改善,尽管翻修组的术后结果较差(分别为33.1对47.2;128.9°对113.6°;p < 0.001)。两组均未出现无菌或感染性假体失败病例。翻修组观察到1例假体周围骨折(0%对2.4%,p = 0.151),初次组观察到3例深静脉血栓形成(DVT)/肺血栓栓塞(PTE)(1例DVT和2例PTE)(1.3%对0%,p = 1.000)。两组最常见的全身性并发症是谵妄(7.4%对14.6%,p = 0.131)。两组在其他全身性并发症发生率上无差异。初次TKA的5年和10年生存率分别为87.2%和62.9%,翻修TKA分别为82.1%和42.2%(p = 0.017)。

结论

基于令人满意的临床结果、与TKA相关的并发症发生率和中期生存率,初次和翻修TKA对八旬老人都是可行的选择。谵妄作为八旬老人初次和翻修TKA中最常见的全身性并发症,需要进行适当管理。

证据级别

IV级。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3865/7509913/982968e18b43/43019_2020_69_Fig1_HTML.jpg

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