Laboratory of Wildlife Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan.
Laboratory of Aquatic Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan.
J Vet Med Sci. 2020 Nov 12;82(11):1619-1626. doi: 10.1292/jvms.20-0339. Epub 2020 Sep 21.
In order to elucidate the relationship between migration period and immunity related to susceptibility, we conducted research on Black-headed gulls (Chroicocephalus ridibundus). We captured 260 gulls and collected their peripheral blood. Their leukocyte (WBC) count, percentages of heterophils (Het) and lymphocytes (Lym), heterophil and lymphocyte ratio (H/L ratio), and CD4 and CD8α expression levels (CD4 and CD8α, respectively) were quantitatively analyzed over three migration periods (Autumn migration, Wintering, Spring migration). In Adult gulls, WBC counts and CD4 levels significantly increased. Moreover, the Het and H/L ratio decreased from the Autumn migration to Wintering. Conversely, only WBC counts and CD4 levels measurements significantly decreased from Wintering to Spring migration (P<0.05). The tested parameters of the Tokyo-bay population show a greater significant difference than the measurements of immunity of the Mikawa-bay population. This study suggests that the migratory period has a negative effect on an aspect of the immune system. Including the period-difference in the immune systems in the local population, it is necessary to investigate the relationship between the ecology of migratory birds and their immunity.
为了阐明迁徙期与易感性相关的免疫之间的关系，我们对黑头鸥（Chroicocephalus ridibundus）进行了研究。我们捕获了 260 只海鸥，并采集了它们的外周血液。我们对三种迁徙期（秋季迁徙、越冬期、春季迁徙）的白细胞（WBC）计数、异嗜粒细胞（Het）和淋巴细胞（Lym）百分比、异嗜粒细胞与淋巴细胞比值（H/L 比值）以及 CD4 和 CD8α 表达水平（分别为 CD4 和 CD8α）进行了定量分析。在成年海鸥中，WBC 计数和 CD4 水平显著增加。此外，从秋季迁徙到越冬期，Het 和 H/L 比值降低。相反，仅从越冬期到春季迁徙，WBC 计数和 CD4 水平显著降低（P<0.05）。东京湾种群的测试参数比三河湾种群的免疫测量值显示出更大的显著差异。本研究表明，迁徙期对免疫系统的一个方面有负面影响。考虑到当地种群的免疫系统的时期差异，有必要调查候鸟的生态学与其免疫之间的关系。
