Ushine Nana, Ozawa Makoto, Nakayama Shouta M M, Ishizuka Mayumi, Kato Takuya, Hayama Shin-Ichi
Laboratory of Wildlife Medicine, Department of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino 180-0023, Japan.
Laboratory of Animal Welfare, Department of Animal Health Technology, Yamazaki University of Animal Health Technology, Hachioji 192-0364, Japan.
Animals (Basel). 2023 Jul 18;13(14):2338. doi: 10.3390/ani13142338.
Lead (Pb), an environmental pollutant, has been widely reported to have contaminated mammals, including humans and birds. This study focuses on the effects of Pb pollution on avian influenza virus (AIV) antibody production. A total of 170 black-headed gulls () were captured in Tokyo Bay (TBP) from January 2019 to April 2020 and in Mikawa Bay (MBP) from November 2019 to April 2021. The gulls were weighed, subjected to blood sampling, and released with a ring band on their tarsus. The samples were used to measure blood Pb levels (BLL) and AIV-specific antibodies. The BLL were compared using the Wilcoxon two-sample test between the period when black-headed gulls arrived and the wintering period, defined by the number of gulls counted in each area. A significant increase was found in the TBP. A decrease in BLL significantly increased antibody titer during wintering in TBP and MBP. Pb pollution had a negative effect on the production of AIV antibodies. These findings suggest that wild birds that were contaminated by Pb in the environment may facilitate the spread of zoonotic diseases, further increasing the possibility that environmental pollutants may threaten human health.
铅（Pb）作为一种环境污染物，已有广泛报道称其污染了包括人类和鸟类在内的哺乳动物。本研究聚焦于铅污染对禽流感病毒（AIV）抗体产生的影响。2019年1月至2020年4月期间，在东京湾（TBP）以及2019年11月至2021年4月期间，在三河湾（MBP）共捕获了170只黑头鸥。对这些海鸥进行称重、采血，然后在其跗跖部套上环志后放生。采集的样本用于测量血铅水平（BLL）和AIV特异性抗体。利用威尔科克森两样本检验，比较黑头鸥到达时期与越冬期（根据各区域统计的海鸥数量定义）的血铅水平。结果发现东京湾的血铅水平显著升高。在东京湾和三河湾越冬期间，血铅水平的降低显著提高了抗体滴度。铅污染对AIV抗体的产生有负面影响。这些发现表明，在环境中受到铅污染的野生鸟类可能会促进人畜共患病的传播，进一步增加了环境污染物可能威胁人类健康的可能性。
