Salazar-Gómez Anuar, Ontiveros-Rodríguez Julio C, Pablo-Pérez Saudy S, Vargas-Díaz M Elena, Garduño-Siciliano Leticia
Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Av. Wilfrido Massieu y M. Stampa, Col. Planetario Lindavista, 77380 Ciudad de México, Mexico.
CONACYT - Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, 58030 Morelia, Michoacán, Mexico.
S Afr J Bot. 2020 Dec;135:240-251. doi: 10.1016/j.sajb.2020.08.020. Epub 2020 Sep 16.
Metabolic syndrome comprises a cluster of metabolic disorders related to the development of cardiovascular disease and type 2 diabetes mellitus. In latter years, plant secondary metabolites have become of special interest because of their potential role in preventing and managing metabolic syndrome. Sesquiterpene lactones constitute a large and diverse group of biologically active compounds widely distributed in several medicinal plants used for the treatment of metabolic disorders. The structural diversity and the broad spectrum of biological activities of these compounds drew significant interests in the pharmacological applications. This review describes selected sesquiterpene lactones that have been experimentally validated for their biological activities related to risk factors of metabolic syndrome, together with their mechanisms of action. The potential beneficial effects of sesquiterpene lactones discussed in this review demonstrate that these substances represent remarkable compounds with a diversity of molecular structure and high biological activity, providing new insights into the possible role in metabolic syndrome management.
代谢综合征包括一系列与心血管疾病和2型糖尿病发展相关的代谢紊乱。近年来，植物次生代谢产物因其在预防和管理代谢综合征中的潜在作用而备受关注。倍半萜内酯是一大类结构多样的生物活性化合物，广泛分布于多种用于治疗代谢紊乱的药用植物中。这些化合物的结构多样性和广泛的生物活性引起了药理学应用方面的极大兴趣。本综述描述了一些倍半萜内酯，它们已通过实验验证了其与代谢综合征风险因素相关的生物活性及其作用机制。本综述中讨论的倍半萜内酯的潜在有益作用表明，这些物质是具有多样分子结构和高生物活性的显著化合物，为其在代谢综合征管理中的可能作用提供了新的见解。
