State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatrics & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Stem Cell Res Ther. 2022 May 16;13(1):201. doi: 10.1186/s13287-022-02852-w.
As global aging accelerates, the prevention and treatment of age-related bone diseases are becoming a critical issue. In the process of senescence, bone marrow mesenchymal stem cells (BMSCs) gradually lose the capability of self-renewal and functional differentiation, resulting in impairment of bone tissue regeneration and disorder of bone tissue homeostasis. Alteration in epigenetic modification is an essential factor of BMSC dysfunction during aging. Its transferability and reversibility provide the possibility to combat BMSC aging by reversing age-related modifications. Emerging evidence demonstrates that epigenetic therapy based on aberrant epigenetic modifications could alleviate the senescence and dysfunction of stem cells. This review summarizes potential therapeutic targets for BMSC aging, introduces some potential approaches to alleviating BMSC aging, and analyzes its prospect in the clinical application of age-related bone diseases.
随着全球老龄化的加速，与年龄相关的骨骼疾病的预防和治疗正成为一个关键问题。在衰老过程中，骨髓间充质干细胞（BMSCs）逐渐丧失自我更新和功能分化的能力，导致骨组织再生受损和骨组织内稳态紊乱。表观遗传修饰的改变是 BMSC 衰老过程中功能障碍的一个重要因素。其可转移性和可逆性为通过逆转与年龄相关的修饰来对抗 BMSC 衰老提供了可能性。新出现的证据表明，基于异常表观遗传修饰的表观遗传疗法可以减轻干细胞的衰老和功能障碍。本综述总结了 BMSC 衰老的潜在治疗靶点，介绍了一些缓解 BMSC 衰老的潜在方法，并分析了其在与年龄相关的骨骼疾病的临床应用中的前景。
