• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人参-三七-川芎（GSC）提取物通过AMPK途径调节线粒体自噬改善糖尿病诱导的内皮细胞衰老。

Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway.

作者信息

Wang Xue, Zhang Jia-Qi, Xiu Cheng-Kui, Yang Jing, Fang Jing-Yi, Lei Yan

机构信息

Beijing Key Laboratory of Research of Chinese Medicine on Preventional and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, 100700 Beijing, China.

Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100700 Beijing, China.

出版信息

Oxid Med Cell Longev. 2020 Sep 7;2020:7151946. doi: 10.1155/2020/7151946. eCollection 2020.

DOI:10.1155/2020/7151946
PMID:32963699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7495226/
Abstract

Vascular endothelial senescence induced by high glucose and palmitate (HG/PA) contributes to endothelial dysfunction, which leads to diabetic cardiovascular complications. Reduction of endothelial senescence may attenuate these pathogenic processes. This study is aimed at determining whether Ginseng-Sanqi-Chuanxiong (GSC) extracts, traditional Chinese medicine, can ameliorate human aortic endothelial cell (HAEC) senescence under HG/PA-stressed conditions and further explore the underlying mechanism. We found that GSC extracts significantly increased antisenescent activity by reducing the HG/PA-induced mitochondrial ROS (mtROS) levels in senescent HAECs. GSC extracts also induced cellular mitophagy formation, which mediated the effect of GSC extracts on mtROS reduction. Apart from this, the data showed that GSC extracts stimulated mitophagy via the AMPK pathway, and upon inhibition of AMPK by pharmacological and genetic inhibitors, GSC extract-mediated mitophagy was abolished which further led to reverse the antisenescence effect. Taken together, these data suggest that GSC extracts prevent HG/PA-induced endothelial senescence and mtROS production by mitophagy regulation via the AMPK pathway. Thus, the induction of mitophagy by GSC extracts may provide a novel therapeutic candidate for cardiovascular protection in metabolic syndrome.

摘要

高糖和棕榈酸酯（HG/PA）诱导的血管内皮细胞衰老会导致内皮功能障碍，进而引发糖尿病心血管并发症。减轻内皮细胞衰老可能会减轻这些致病过程。本研究旨在确定中药人参-三七-川芎（GSC）提取物是否能改善HG/PA应激条件下人主动脉内皮细胞（HAEC）的衰老，并进一步探究其潜在机制。我们发现，GSC提取物通过降低HG/PA诱导的衰老HAEC中线粒体活性氧（mtROS）水平，显著增强了抗衰老活性。GSC提取物还诱导了细胞线粒体自噬的形成，这介导了GSC提取物对mtROS降低的作用。除此之外，数据显示GSC提取物通过AMPK途径刺激线粒体自噬，并且在使用药理学和基因抑制剂抑制AMPK后，GSC提取物介导的线粒体自噬被消除，这进一步导致抗衰老作用的逆转。综上所述，这些数据表明GSC提取物通过AMPK途径调控线粒体自噬，从而预防HG/PA诱导的内皮细胞衰老和mtROS产生。因此，GSC提取物诱导的线粒体自噬可能为代谢综合征中的心血管保护提供一种新的治疗候选方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/8852d7c40b66/OMCL2020-7151946.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/976070f006cb/OMCL2020-7151946.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/a071a3e1d70a/OMCL2020-7151946.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/713940a2faf3/OMCL2020-7151946.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/b6bb1df989be/OMCL2020-7151946.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/27132d24b844/OMCL2020-7151946.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/ef9d45ecf9f2/OMCL2020-7151946.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/032062867824/OMCL2020-7151946.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/d1b787be6ee0/OMCL2020-7151946.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/a2a9c74832bc/OMCL2020-7151946.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/cf5535d54216/OMCL2020-7151946.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/8852d7c40b66/OMCL2020-7151946.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/976070f006cb/OMCL2020-7151946.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/a071a3e1d70a/OMCL2020-7151946.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/713940a2faf3/OMCL2020-7151946.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/b6bb1df989be/OMCL2020-7151946.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/27132d24b844/OMCL2020-7151946.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/ef9d45ecf9f2/OMCL2020-7151946.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/032062867824/OMCL2020-7151946.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/d1b787be6ee0/OMCL2020-7151946.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/a2a9c74832bc/OMCL2020-7151946.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/cf5535d54216/OMCL2020-7151946.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2397/7495226/8852d7c40b66/OMCL2020-7151946.011.jpg

相似文献

1
Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway.人参-三七-川芎（GSC）提取物通过AMPK途径调节线粒体自噬改善糖尿病诱导的内皮细胞衰老。
Oxid Med Cell Longev. 2020 Sep 7;2020:7151946. doi: 10.1155/2020/7151946. eCollection 2020.
2
C1q/TNF-related protein-9 attenuates palmitic acid-induced endothelial cell senescence via increasing autophagy.C1q/TNF 相关蛋白-9 通过增加自噬来减轻棕榈酸诱导的内皮细胞衰老。
Mol Cell Endocrinol. 2021 Feb 5;521:111114. doi: 10.1016/j.mce.2020.111114. Epub 2020 Dec 7.
3
Ginseng-Sanqi-Chuanxiong (GSC) extracts attenuate d-galactose-induced vascular aging in mice via inhibition of endothelial progenitor cells senescence.人参-三七-川芎（GSC）提取物通过抑制内皮祖细胞衰老减轻d-半乳糖诱导的小鼠血管衰老。
Heliyon. 2024 Feb 7;10(4):e25253. doi: 10.1016/j.heliyon.2024.e25253. eCollection 2024 Feb 29.
4
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.硫化氢调节线粒体形态促进高糖高棕榈酸诱导的内皮细胞自噬
J Cell Mol Med. 2017 Dec;21(12):3190-3203. doi: 10.1111/jcmm.13223. Epub 2017 Jun 13.
5
PTEN inhibition attenuates endothelial cell apoptosis in coronary heart disease via modulating the AMPK-CREB-Mfn2-mitophagy signaling pathway.PTEN 抑制通过调节 AMPK-CREB-Mfn2-线粒体自噬信号通路减轻冠心病内皮细胞凋亡。
J Cell Physiol. 2020 May;235(5):4878-4889. doi: 10.1002/jcp.29366. Epub 2019 Oct 25.
6
Yiqihuoxue decoction (GSC) inhibits mitochondrial fission through the AMPK pathway to ameliorate EPCs senescence and optimize vascular aging transplantation regimens.益气活血汤（GSC）通过AMPK途径抑制线粒体分裂，以改善内皮祖细胞衰老并优化血管衰老移植方案。
Chin Med. 2024 Oct 14;19(1):143. doi: 10.1186/s13020-024-01008-7.
7
"Effects of extracts from Renshen (Radix Ginseng), Sanqi (Radix Notoginseng), and Chuanxiong (Rhizoma Chuanxiong) on F-actin in senescent microvascular endothelial cells".人参、三七和川芎提取物对衰老微血管内皮细胞中F-肌动蛋白的影响
J Tradit Chin Med. 2020 Jun;40(3):376-385. doi: 10.19852/j.cnki.jtcm.2020.03.003.
8
Salvianolic acid B protects against oxLDL-induced endothelial dysfunction under high-glucose conditions by downregulating ROCK1-mediated mitophagy and apoptosis.丹酚酸 B 可通过下调 ROCK1 介导线粒体自噬和凋亡来防止高糖环境下 oxLDL 诱导的内皮功能障碍。
Biochem Pharmacol. 2020 Apr;174:113815. doi: 10.1016/j.bcp.2020.113815. Epub 2020 Jan 20.
9
Endothelial mitochondrial senescence accelerates cardiovascular disease in antiretroviral-receiving HIV patients.内皮细胞线粒体衰老加速接受抗逆转录病毒治疗的 HIV 患者的心血管疾病。
Toxicol Lett. 2019 Dec 15;317:13-23. doi: 10.1016/j.toxlet.2019.09.018. Epub 2019 Sep 25.
10
Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence.慢性核苷逆转录酶抑制剂破坏线粒体稳态并促进内皮细胞早衰。
Toxicol Sci. 2019 Dec 1;172(2):445-456. doi: 10.1093/toxsci/kfz203.

引用本文的文献

1
Decoding interaction between mitochondria and endoplasmic reticulum in ischemic myocardial injury: targeting natural medicines.解析缺血性心肌损伤中线粒体与内质网之间的相互作用：以天然药物为靶点
Front Pharmacol. 2025 Feb 28;16:1536773. doi: 10.3389/fphar.2025.1536773. eCollection 2025.
2
Pathological roles of mitochondrial dysfunction in endothelial cells during the cerebral no-reflow phenomenon: A review.脑无复流现象中内皮细胞线粒体功能障碍的病理作用：综述
Medicine (Baltimore). 2024 Dec 20;103(51):e40951. doi: 10.1097/MD.0000000000040951.
3
Yiqihuoxue decoction (GSC) inhibits mitochondrial fission through the AMPK pathway to ameliorate EPCs senescence and optimize vascular aging transplantation regimens.

本文引用的文献

1
Thyroid hormone (T) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.甲状腺激素（T）通过线粒体生物发生和 MTOR 介导的线粒体自噬刺激棕色脂肪组织的激活。
Autophagy. 2019 Jan;15(1):131-150. doi: 10.1080/15548627.2018.1511263. Epub 2018 Sep 13.
2
The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II.促氧化剂衔接蛋白 p66SHC 通过破坏线粒体完整性和招募 LC3-II 促进 B 细胞自噬。
Autophagy. 2018;14(12):2117-2138. doi: 10.1080/15548627.2018.1505153. Epub 2018 Sep 6.
3
Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation.
益气活血汤（GSC）通过AMPK途径抑制线粒体分裂，以改善内皮祖细胞衰老并优化血管衰老移植方案。
Chin Med. 2024 Oct 14;19(1):143. doi: 10.1186/s13020-024-01008-7.
4
Investigating the interplay between mitophagy and diabetic neuropathy: Uncovering the hidden secrets of the disease pathology.探究自噬与糖尿病神经病变之间的相互作用：揭示疾病病理的隐藏秘密。
Pharmacol Res. 2024 Oct;208:107394. doi: 10.1016/j.phrs.2024.107394. Epub 2024 Sep 3.
5
The Role of Endothelial Cell Mitophagy in Age-Related Cardiovascular Diseases.内皮细胞线粒体自噬在年龄相关性心血管疾病中的作用
Aging Dis. 2024 Jul 26;16(4):2151-2176. doi: 10.14336/AD.2024.0788.
6
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction.血管内皮损伤相关疾病发病机制和治疗策略的新见解：聚焦于线粒体功能障碍。
Angiogenesis. 2024 Nov;27(4):623-639. doi: 10.1007/s10456-024-09938-4. Epub 2024 Jul 26.
7
Chinese botanical drugs targeting mitophagy to alleviate diabetic kidney disease, a comprehensive review.靶向线粒体自噬以缓解糖尿病肾病的中药：一项综述
Front Pharmacol. 2024 May 13;15:1360179. doi: 10.3389/fphar.2024.1360179. eCollection 2024.
8
IL-33 Reduces Saturated Fatty Acid Accumulation in Mouse Atherosclerotic Foci.白细胞介素-33减少小鼠动脉粥样硬化病灶中的饱和脂肪酸积累。
Nutrients. 2024 Apr 17;16(8):1195. doi: 10.3390/nu16081195.
9
Mechanism of traditional Chinese medicine in elderly diabetes mellitus and a systematic review of its clinical application.中医治疗老年糖尿病的机制及其临床应用的系统评价
Front Pharmacol. 2024 Mar 6;15:1339148. doi: 10.3389/fphar.2024.1339148. eCollection 2024.
10
Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity.传统中药及其活性成分通过调节自噬活性减轻糖尿病中的血管损伤。
Front Pharmacol. 2024 Mar 4;15:1355246. doi: 10.3389/fphar.2024.1355246. eCollection 2024.
线粒体靶向药物可刺激自噬并阻断结肠癌细胞增殖。
J Biol Chem. 2018 Sep 21;293(38):14891-14904. doi: 10.1074/jbc.RA117.001469. Epub 2018 Aug 7.
4
AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation.AMPKα2 通过磷酸化 PINK1 增强线粒体自噬来保护心脏免于心力衰竭的发生。
Circ Res. 2018 Mar 2;122(5):712-729. doi: 10.1161/CIRCRESAHA.117.312317. Epub 2017 Dec 28.
5
GLP-1 and Ghrelin Attenuate High Glucose/High Lipid-Induced Apoptosis and Senescence of Human Microvascular Endothelial Cells.胰高血糖素样肽-1和胃饥饿素减轻高糖/高脂诱导的人微血管内皮细胞凋亡和衰老。
Cell Physiol Biochem. 2017;44(5):1842-1855. doi: 10.1159/000485820. Epub 2017 Dec 7.
6
MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling.MTORC1 调节氧化磷酸化解偶联后诱导的非特异性自噬和线粒体自噬。
Mol Cell Biol. 2017 Nov 13;37(23). doi: 10.1128/MCB.00441-17. Print 2017 Dec 1.
7
Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro.生物活性化合物对体外衰老及衰老相关分泌表型成分的影响。
Food Funct. 2017 Jul 19;8(7):2394-2418. doi: 10.1039/c7fo00161d.
8
IL-1β Inhibition in Cardiovascular Complications Associated to Diabetes Mellitus.白细胞介素-1β抑制在糖尿病相关心血管并发症中的作用
Front Pharmacol. 2017 Jun 13;8:363. doi: 10.3389/fphar.2017.00363. eCollection 2017.
9
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.硫化氢调节线粒体形态促进高糖高棕榈酸诱导的内皮细胞自噬
J Cell Mol Med. 2017 Dec;21(12):3190-3203. doi: 10.1111/jcmm.13223. Epub 2017 Jun 13.
10
TXNIP regulates mitophagy in retinal Müller cells under high-glucose conditions: implications for diabetic retinopathy.硫氧还蛋白相互作用蛋白在高糖条件下调节视网膜穆勒细胞中的线粒体自噬：对糖尿病视网膜病变的影响
Cell Death Dis. 2017 May 11;8(5):e2777. doi: 10.1038/cddis.2017.190.