Nephrology and Urology Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Nephrology and Urology Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Pharmacol Res. 2024 Oct;208:107394. doi: 10.1016/j.phrs.2024.107394. Epub 2024 Sep 3.
Mitophagy, the cellular process of selectively eliminating damaged mitochondria, plays a crucial role in maintaining metabolic balance and preventing insulin resistance, both key factors in type 2 diabetes mellitus (T2DM) development. When mitophagy malfunctions in diabetic neuropathy, it triggers a cascade of metabolic disruptions, including reduced energy production, increased oxidative stress, and cell death, ultimately leading to various complications. Thus, targeting mitophagy to enhance the process may have emerged as a promising therapeutic strategy for T2DM and its complications. Notably, plant-derived compounds with β-cell protective and mitophagy-stimulating properties offer potential as novel therapeutic agents. This review highlights the intricate mechanisms linking mitophagy dysfunction to T2DM and its complications, particularly neuropathy, elucidating potential therapeutic interventions for this debilitating disease.
自噬，即细胞选择性清除受损线粒体的过程，在维持代谢平衡和预防胰岛素抵抗方面发挥着关键作用，而这两者都是 2 型糖尿病（T2DM）发展的关键因素。当糖尿病性神经病变中的自噬功能出现故障时，会引发一系列代谢紊乱，包括能量产生减少、氧化应激增加和细胞死亡，最终导致各种并发症。因此，靶向自噬以增强该过程可能成为治疗 T2DM 及其并发症的有前途的策略。值得注意的是，具有β细胞保护和自噬刺激特性的植物源性化合物可能成为新的治疗药物。本综述强调了自噬功能障碍与 T2DM 及其并发症（特别是神经病变）之间的复杂机制，为这种使人衰弱的疾病提供了潜在的治疗干预措施。
