Seifinadergoli Zahra, Nahidi Fatemeh, Safaiyan Abdolrasoul, Javadzadeh Yousef, Eteraf Oskouei Tahereh
Department of Midwifery & Reproductive Health, School of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Biostatistics and Epidemiology, Faculty of Health, Road Traffic Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Caring Sci. 2020 Aug 18;9(3):162-167. doi: 10.34172/jcs.2020.024. eCollection 2020 Aug.
Due to the increasing resistance to synthetic antifungal drugs, the use of drugs with a natural origin, with low side effects and low prices is a priority. This study was performed to evaluate the effect of topical honey gel and clotrimazole cream in treatment of signs of vaginal candidiasis. This randomized clinical trial was conducted to evaluate the topical use of honey and clotrimazole in the signs of vulvovaginal candidiasis in clinics and medical centers in Tabriz. The study was performed on 106 non-pregnant women (18 to 45 years old) who had clinical signs of candidiasis. Patients were randomly divided into two groups receiving honey gel and clotrimazole vaginal cream (53 people per group). Each group was treated for 8 days. Before, 4, and 8 days after the intervention, patients recorded the sings of disease and possible side effects of drugs using a researcher-made questionnaire. The results were analyzed using SPSS software ver. 22. Inter-group comparison was carried out using McNemar, Cochran Q and independent t tests. P value < 0.05 was considered statistically significant. sults: In the three evaluation periods, a significant reduction in the sings was observed compared to the before starting of treatment regimes. The results of the cultures were similar and there was no significant difference between the two honey gel and clotrimazole cream groups. Our results may suggest that honey gel could have promising benefits in the treatment of vulvovaginal candidiasis as the main drug or as an adjunct to other antifungal drugs.
由于对合成抗真菌药物的耐药性不断增加，使用天然来源、副作用小且价格低廉的药物成为当务之急。本研究旨在评估局部应用蜂蜜凝胶和克霉唑乳膏治疗阴道念珠菌病症状的效果。这项随机临床试验旨在评估在大不里士的诊所和医疗中心局部使用蜂蜜和克霉唑治疗外阴阴道念珠菌病症状的效果。该研究对106名有念珠菌病临床症状的非妊娠妇女（18至45岁）进行。患者被随机分为两组，分别接受蜂蜜凝胶和克霉唑阴道乳膏治疗（每组53人）。每组治疗8天。在干预前、干预后4天和8天，患者使用研究人员制作的问卷记录疾病症状和药物可能的副作用。结果使用SPSS软件版本22进行分析。组间比较采用McNemar检验、Cochran Q检验和独立t检验。P值<0.05被认为具有统计学意义。结果：在三个评估期内，与治疗方案开始前相比，症状有显著减轻。培养结果相似，蜂蜜凝胶组和克霉唑乳膏组之间无显著差异。我们的结果可能表明，蜂蜜凝胶作为主要药物或作为其他抗真菌药物的辅助药物，在外阴阴道念珠菌病的治疗中可能具有有益的效果。
