Kramer J W, Nottingham S, Robinette J, Lenz G, Sylvester S, Dessouky M I
Diabetes. 1980 Jul;29(7):558-65. doi: 10.2337/diab.29.7.558.
Spontaneous diabetes mellitus has been characterized in a line of nonobese purebred keeshond dogs as an insulin-requiring hereditary disorder with onset at between 2 and 6 mo of age. Diabetic dogs developed cataracts, became ketotic, hyperglycemic, hypercholesterolemic, lipemic, and hypoinsulinemic. Basal glucagon, cortisol, and T4 serum concentrations and responses to ACTH, TSH, and arginine were normal. Light microscopic studies of the pancreas by immunocytochemical procedures revealed the absence of islet B cells, the presence of A cells, and solitary B cells. Diabetic dogs had poor fecundity, and a single puberal diabetic male had poor semen quality and was unable to sire pups. Parents of diabetics and nondiabetic siblings were normal. This spontaneous form of diabetes mellitus, with similar lesions to the insulin-dependent diabetes of people, will be a valuable aid to comparative biomedical research of diabetes mellitus.
自发性糖尿病已在一组非肥胖纯种荷兰卷尾狮毛犬中被表征为一种需要胰岛素治疗的遗传性疾病，发病年龄在2至6个月之间。患糖尿病的犬出现白内障、酮血症、高血糖、高胆固醇血症、脂血症和低胰岛素血症。基础胰高血糖素、皮质醇和血清T4浓度以及对促肾上腺皮质激素、促甲状腺激素和精氨酸的反应均正常。通过免疫细胞化学方法对胰腺进行的光镜研究显示胰岛B细胞缺失、A细胞存在以及单个B细胞存在。患糖尿病的犬繁殖力差，一只青春期患糖尿病的雄性犬精液质量差，无法使母犬受孕。糖尿病犬的父母和非糖尿病的兄弟姐妹均正常。这种自发性糖尿病形式与人类胰岛素依赖型糖尿病有相似病变，将对糖尿病的比较生物医学研究有很大帮助。
