Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
Microbiology Division, Tulane National Primate Research Center, Tulane University, Covington, LA, 70433, USA.
J Neurovirol. 2020 Dec;26(6):945-951. doi: 10.1007/s13365-020-00907-3. Epub 2020 Sep 22.
Varicella and zoster, produced by varicella-zoster virus (VZV), are associated with an increased risk of stroke that may be due to persistent inflammation and hypercoagulability. Because substance P is associated with inflammation, hypercoagulability, and atherosclerotic plaque rupture that may contribute to increased stroke risk after VZV infection, we measured serum substance P in simian varicella virus-infected rhesus macaques. We found significantly increased and persistent serum substance P concentrations during varicella and zoster compared with pre-inoculation, supporting the hypothesis that VZV-induced increases in serum substance P may contribute to increased stroke risk associated with VZV infection.
水痘和带状疱疹由水痘-带状疱疹病毒（VZV）引起，与中风风险增加相关，其可能是由于持续的炎症和高凝状态所致。P 物质与炎症、高凝状态以及可能导致 VZV 感染后中风风险增加的动脉粥样硬化斑块破裂有关，因此我们检测了感染猴痘病毒的恒河猴血清中的 P 物质。我们发现与接种前相比，在水痘和带状疱疹期间血清 P 物质浓度显著升高且持续，这支持了这样一种假设，即 VZV 诱导的血清 P 物质增加可能导致与 VZV 感染相关的中风风险增加。
