Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, Co, 80045, USA.
Division of Microbiology, Tulane National Primate Research Center, Tulane University, 18703 Three Rivers Road, Covington, LA, 70433, USA.
J Neurovirol. 2024 Feb;30(1):86-99. doi: 10.1007/s13365-024-01196-w. Epub 2024 Mar 7.
Simian varicella virus (SVV) produces peripheral inflammatory responses during varicella (primary infection) and zoster (reactivation) in rhesus macaques (RM). However, it is unclear if peripheral measures are accurate proxies for central nervous system (CNS) responses. Thus, we analyzed cytokine and Aβ42/Aβ40 changes in paired serum and cerebrospinal fluid (CSF) during the course of infection. During varicella and zoster, every RM had variable changes in serum and CSF cytokine and Aβ42/Aβ40 levels compared to pre-inoculation levels. Overall, peripheral infection appears to affect CNS cytokine and Aβ42/Aβ40 levels independent of serum responses, suggesting that peripheral disease may contribute to CNS disease.
猿猴水痘病毒（SVV）在恒河猴（RM）的水痘（原发感染）和带状疱疹（再激活）期间产生外周炎症反应。然而，外周测量是否准确代表中枢神经系统（CNS）反应尚不清楚。因此，我们分析了感染过程中配对血清和脑脊液（CSF）中细胞因子和 Aβ42/Aβ40 的变化。在水痘和带状疱疹期间，与接种前水平相比，每只 RM 的血清和 CSF 细胞因子和 Aβ42/Aβ40 水平均有不同程度的变化。总体而言，外周感染似乎会影响 CNS 细胞因子和 Aβ42/Aβ40 水平，而与血清反应无关，这表明外周疾病可能导致 CNS 疾病。
