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Totally tubular, dude: rethinking DKD pathogenesis in the wake of SGLT2i data.

作者信息

Yu Samuel Mon-Wei, Leventhal Jeremy S, Cravedi Paolo

机构信息

Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Division of Nephrology, White Plains Hospital, White Plains, NY, USA.

出版信息

J Nephrol. 2021 Jun;34(3):629-631. doi: 10.1007/s40620-020-00868-0.

DOI:10.1007/s40620-020-00868-0
PMID:32965657
Abstract
摘要

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Totally tubular, dude: rethinking DKD pathogenesis in the wake of SGLT2i data.完全是肾小管的问题,伙计:基于SGLT2抑制剂的数据重新思考糖尿病肾病的发病机制。
J Nephrol. 2021 Jun;34(3):629-631. doi: 10.1007/s40620-020-00868-0.
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Front Endocrinol (Lausanne). 2022 Jun 28;13:924299. doi: 10.3389/fendo.2022.924299. eCollection 2022.
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Role of the adaptive immune system in diabetic kidney disease.适应性免疫系统在糖尿病肾病中的作用。
J Diabetes Investig. 2022 Feb;13(2):213-226. doi: 10.1111/jdi.13725. Epub 2021 Dec 21.
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Kidney Biopsy in Type 2 Diabetic Patients: Critical Reflections on Present Indications and Diagnostic Alternatives.

本文引用的文献

1
Molecular Profile of Barrett's Esophagus and Gastroesophageal Reflux Disease in the Development of Translational Physiological and Pharmacological Studies.巴雷特食管和胃食管反流病的分子特征在转化生理和药理研究中的发展。
Int J Mol Sci. 2020 Sep 3;21(17):6436. doi: 10.3390/ijms21176436.
2
SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition.钠-葡萄糖协同转运蛋白2(SGLT2)抑制通过促进酮体诱导的哺乳动物雷帕霉素靶蛋白复合体1(mTORC1)抑制介导对糖尿病肾病的保护作用。
Cell Metab. 2020 Sep 1;32(3):404-419.e6. doi: 10.1016/j.cmet.2020.06.020. Epub 2020 Jul 28.
3
Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors.
2 型糖尿病患者的肾脏活检:对现有适应证和诊断替代方案的批判性思考。
Int J Mol Sci. 2021 May 21;22(11):5425. doi: 10.3390/ijms22115425.
4
Nephroprotection by SGLT2i in CKD Patients: May It Be Modulated by Low-Protein Plant-Based Diets?SGLT2抑制剂对慢性肾脏病患者的肾脏保护作用:是否会受到低蛋白植物性饮食的调节?
Front Med (Lausanne). 2020 Dec 3;7:622593. doi: 10.3389/fmed.2020.622593. eCollection 2020.
5
Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in diabetic mice.恩格列净可减轻糖尿病小鼠的足细胞病变并增强肾小球nephrin表达。
World J Diabetes. 2020 Dec 15;11(12):596-610. doi: 10.4239/wjd.v11.i12.596.
营养和氧剥夺信号受损及自噬流不足在糖尿病肾病发病机制中的作用:对理解钠-葡萄糖共转运蛋白 2 抑制剂作用的启示。
J Am Soc Nephrol. 2020 May;31(5):907-919. doi: 10.1681/ASN.2020010010. Epub 2020 Apr 10.
4
The tubular hypothesis of nephron filtration and diabetic kidney disease.管状假说在肾单位滤过和糖尿病肾病中的作用。
Nat Rev Nephrol. 2020 Jun;16(6):317-336. doi: 10.1038/s41581-020-0256-y. Epub 2020 Mar 9.
5
The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial.在 RED 随机、双盲试验中,二甲双胍治疗的 2 型糖尿病患者中,SGLT2 抑制剂达格列净的肾脏血流动力学效应是由肾小球后血管舒张引起的,而不是由肾小球前血管收缩引起的。
Kidney Int. 2020 Jan;97(1):202-212. doi: 10.1016/j.kint.2019.09.013. Epub 2019 Oct 10.
6
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.卡格列净与 2 型糖尿病和肾病患者的肾脏结局。
N Engl J Med. 2019 Jun 13;380(24):2295-2306. doi: 10.1056/NEJMoa1811744. Epub 2019 Apr 14.
7
SGLT2 inhibitor dapagliflozin limits podocyte damage in proteinuric nondiabetic nephropathy.SGLT2 抑制剂达格列净可减少蛋白尿非糖尿病肾病的足细胞损伤。
JCI Insight. 2018 Aug 9;3(15). doi: 10.1172/jci.insight.98720.
8
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.肾小管 Sirt1 通过表观遗传抑制足细胞中 Claudin-1 的过度表达来减轻糖尿病白蛋白尿。
Nat Med. 2013 Nov;19(11):1496-504. doi: 10.1038/nm.3363. Epub 2013 Oct 20.
9
Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target.家族性肾性糖尿和 SGLT2:从孟德尔性状到治疗靶点。
Clin J Am Soc Nephrol. 2010 Jan;5(1):133-41. doi: 10.2215/CJN.04010609. Epub 2009 Nov 5.