98763Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
58987University of Ibadan, Ibadan, Nigeria.
J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20938002. doi: 10.1177/2515690X20938002.
Liver diseases have now become a global canker due to increasing drug abuse and several viral infections. The current medicines on the market are woefully inadequate and limited in the application against these diseases. Fortunately, medicinal plants continue to serve as a potential source of drug discovery that could be explored to improve the situation. The present study, therefore, evaluated the hepatoprotective activities of the aqueous extract of various parts (leaves, flower and stem) of L on carbon tetrachloride (CCl)- and acetaminophen-induced toxicity in rats. The protective effect of the plant was assessed using biochemical parameters, histology, levels of liver antioxidants, and expression of some pro-inflammatory cytokines (NF-κβ and IL-1) in the liver. The leaves and stem extracts, orally administered for 7 days at 250 mg/kg, effectively prevented CCl-induced elevation of serum biochemical parameters, prooxidants, as well as the expression of NFk-B and IL-1, which were comparable to Silymarin (standard drug). A comparative histopathological analyses of the liver exhibited virtually normal architecture compared with CCl-treated group. The findings showed that the hepatoprotective effect of was probably due to the inhibition of oxidative stress and downregulation of proinflammatory cytokines by the effective parts of the medicinal plant.
肝脏疾病现已成为全球性顽疾，这是由于药物滥用和多种病毒感染的增加所致。目前市场上的药物在治疗这些疾病方面明显不足且应用有限。幸运的是，药用植物仍然是药物发现的潜在来源，可以探索它们来改善这种情况。因此，本研究评估了不同部位（叶、花和茎）的水提物对四氯化碳（CCl）和对乙酰氨基酚诱导的大鼠肝毒性的保护作用。使用生化参数、组织学、肝抗氧化剂水平和肝脏中一些促炎细胞因子（NF-κβ和 IL-1）的表达来评估植物的保护作用。该植物的叶和茎提取物以 250mg/kg 的剂量口服给药 7 天，可有效预防 CCl 诱导的血清生化参数、促氧化剂以及 NFk-B 和 IL-1 的升高，与水飞蓟素（标准药物）相当。肝的组织病理学比较分析显示，与 CCl 处理组相比，其具有几乎正常的结构。研究结果表明，该药用植物的有效部位可能通过抑制氧化应激和下调促炎细胞因子发挥其肝保护作用。
