College of Chemistry & Materials Science, Shanghai Normal University, No. 100 Guilin Road, Shanghai, 200234, PR China.
Burn & Plastic Department, School of Medicine Affiliated Ruijin Hospital, Shanghai Jiao Tong University, No. 197 Ruijin Road, Shanghai, 200020, PR China.
Nanomedicine (Lond). 2020 Aug;15(23):2241-2253. doi: 10.2217/nnm-2020-0053. Epub 2020 Sep 24.
To develop an effective strategy for increasing angiogenesis at diabetic wound sites and thereby accelerating wound healing. A micropatterned nanofibrous scaffold with bioglass nanoparticles encapsulated inside coaxial fibers was prepared by electrospinning. Si ions could be released in a sustained manner from the scaffolds. The hierarchical micro-/nano-structure of the scaffold was found to act as a temporary extracellular matrix to promote endothelial cell adhesion and growth. The scaffold greatly improved angiogenesis and collagen deposition at the wound site, which shortened the healing period of diabetic wounds. This study provides a promising therapeutic option for chronic diabetic wounds with improved angiogenesis.
为了在糖尿病创面处有效促进血管生成，从而加速创面愈合，我们开发了一种策略。我们通过静电纺丝制备了一种同轴纤维内包埋生物玻璃纳米粒子的微纳图案化纳米纤维支架。Si 离子可以从支架中持续释放。支架的分级微/纳结构可以作为临时细胞外基质促进内皮细胞黏附和生长。支架极大地促进了血管生成和胶原在创面处的沉积，从而缩短了糖尿病创面的愈合时间。该研究为改善血管生成的慢性糖尿病创面提供了一种有前景的治疗选择。
