血浆铬与中国成年人代谢综合征的关联：病例对照研究。

Association of plasma chromium with metabolic syndrome among Chinese adults: a case-control study.

机构信息

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.

Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.

出版信息

Nutr J. 2020 Sep 23;19(1):107. doi: 10.1186/s12937-020-00625-w.

DOI:10.1186/s12937-020-00625-w

PMID:32967680

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7513538/

Abstract

BACKGROUD

Chromium has been suggested playing a role in alleviating diabetes, insulin resistance and lipid anomalies, but the effect on metabolic syndrome (MetS) in humans remains controversial.

METHODS

We conducted a matched case-control study in a Chinese population, involving 2141 MetS cases and 2141 healthy controls, which were 1:1 matched by age (±2 years) and sex. Plasma chromium was measured by inductively coupled plasma mass spectrometry.

RESULTS

Plasma chromium levels were lower in MetS group than in control group (mean: 4.36 μg/L and 4.66 μg/L, respectively, P < 0.001), and progressively decreased with the number of MetS components (P for trend < 0.001). After adjustment for potential confounding factors, the odds ratios (95% confidence intervals) for MetS across increasing quartiles of plasma chromium levels were 1 (reference), 0.84 (0.67-1.05), 0.76 (0.61-0.95), and 0.62 (0.49-0.78), respectively (P for trend < 0.001). For the components of MetS (high waist circumference, high triglycerides and high blood glucose), the odds ratios (95% confidence intervals) of the highest quartiles were 0.77 (0.61-0.95), 0.67 (0.55-0.80), and 0.53 (0.44-0.64), respectively (P for trend < 0.05).

CONCLUSIONS

Our results indicated that plasma chromium levels were inversely associated with MetS in Chinese adults. The association may be explained by the relations between plasma chromium levels and high waist circumference, and the triglycerides and blood glucose levels.

摘要

背景

铬被认为在缓解糖尿病、胰岛素抵抗和血脂异常方面发挥作用，但它对人类代谢综合征（MetS）的影响仍存在争议。

方法

我们在中国人群中进行了一项匹配病例对照研究，共纳入 2141 例 MetS 患者和 2141 例健康对照，按年龄（±2 岁）和性别 1:1 匹配。采用电感耦合等离子体质谱法检测血浆铬水平。

结果

MetS 组血浆铬水平低于对照组（平均值分别为 4.36μg/L 和 4.66μg/L，P<0.001），且随 MetS 成分数的增加而逐渐降低（趋势 P<0.001）。调整潜在混杂因素后，血浆铬水平递增 quartiles 与 MetS 的比值比（95%置信区间）分别为 1（参考）、0.84（0.67-1.05）、0.76（0.61-0.95）和 0.62（0.49-0.78）（趋势 P<0.001）。对于 MetS 的各个成分（高腰围、高甘油三酯和高血糖），最高 quartiles 的比值比（95%置信区间）分别为 0.77（0.61-0.95）、0.67（0.55-0.80）和 0.53（0.44-0.64）（趋势 P<0.05）。