Department of Food and Nutrition, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea.
Department of Research and Education, University of Missouri Research Reactor, Columbia, MO 65211, USA.
Int J Environ Res Public Health. 2018 Apr 4;15(4):682. doi: 10.3390/ijerph15040682.
Although in vivo and in vitro studies have shown that chromium has protective effects against metabolic diseases, few studies have examined this association in humans. The present study examined chronic chromium (Cr) exposure among Koreans based on the measurement of toenail Cr concentrations, and analyzed the associations between toenail Cr concentrations and metabolic syndrome (MetS) and its components. We conducted a cross-sectional analysis using baseline data from the prospective cohort study in the Yeungnam area of South Korea that included 232 men and 268 women. Toenail Cr concentration was quantified by neutron activation analysis, and metabolic biomarker levels were obtained through medical examinations. The odd ratios (OR) of prevalent MetS and its components in correlation with Cr concentrations were calculated using multivariable logistic regression. After multiple confounding variables were adjusted for, participants with higher concentrations of Cr had a prevalence rate of MetS similar to those with lower concentrations (OR, 1.84; 95% confidence interval, 0.65-5.23). Our results do not support an association between long-term exposure to Cr and a lower prevalence of MetS in Koreans, whose Cr concentrations are relatively low compared to those of populations in Europe and the United States.
尽管体内和体外研究表明铬对代谢疾病具有保护作用，但很少有研究在人类中对此关联进行检验。本研究根据对韩国人脚趾甲中铬浓度的测量，考察了慢性铬（Cr）暴露情况，并分析了脚趾甲 Cr 浓度与代谢综合征（MetS）及其成分之间的关联。我们对韩国荣州地区前瞻性队列研究的基线数据进行了横断面分析，该研究共纳入了 232 名男性和 268 名女性。通过中子激活分析对脚趾甲 Cr 浓度进行定量，并通过体检获得代谢生物标志物水平。使用多变量逻辑回归计算与 Cr 浓度相关的常见 MetS 及其成分的比值比（OR）。在调整了多个混杂变量后，Cr 浓度较高的参与者的 MetS 患病率与浓度较低的参与者相似（OR，1.84；95%置信区间，0.65-5.23）。我们的结果不支持韩国人长期接触 Cr 与 MetS 患病率降低之间存在关联，与欧洲和美国人群相比，韩国人的 Cr 浓度相对较低。
