Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Nutrients. 2021 Dec 18;13(12):4544. doi: 10.3390/nu13124544.
Molybdenum has been found to be associated with metabolic disorders. However, the relationship between molybdenum and metabolic syndrome (MetS) is still unclear. A large case-control study was conducted in a Chinese population from the baseline of Ezhou-Shenzhen cohort. A total of 5356 subjects were included with 2678 MetS and 2678 controls matched by sex and age (±2 years). Medians (IQRs) of plasma molybdenum concentrations were 1.24 μg/L for MetS cases and 1.46 μg/L for controls. After adjustment for multiple covariates, the odds ratio (OR) and 95% confidence intervals (CIs) for MetS were 1.00 (reference), 0.71 (0.59-0.84), 0.56 (0.46-0.68), and 0.47 (0.39-0.58) across quartiles of plasma molybdenum, and per SD increment of log-transformed molybdenum was associated with a 23% lower risk of MetS. In the spline analysis, the risk of MetS and its components decreased steeply with increasing molybdenum and followed by a plateau when the cutoff point was observed around 2.0 μg/L. The dose-dependent relationship of molybdenum with MetS remained consistent when considering other essential elements in the Bayesian kernel machine regression (BKMR) model. In our study, higher plasma molybdenum was significantly associated with a lower risk of MetS, as well as its components, in a dose-response manner.
钼已被发现与代谢紊乱有关。然而，钼与代谢综合征（MetS）之间的关系尚不清楚。在中国人群中进行了一项大型病例对照研究，该研究基于鄂州-深圳队列的基线。共纳入 5356 例受试者，其中 2678 例患有代谢综合征，2678 例按性别和年龄（±2 岁）匹配对照。MetS 病例的血浆钼浓度中位数（IQR）为 1.24μg/L，对照组为 1.46μg/L。调整了多个协变量后，MetS 的优势比（OR）和 95%置信区间（CI）分别为 1.00（参考）、0.71（0.59-0.84）、0.56（0.46-0.68）和 0.47（0.39-0.58），跨越血浆钼四分位数，log 转换钼的每 SD 增量与 MetS 风险降低 23%相关。在样条分析中，MetS 及其各组分的风险随着钼的增加而急剧下降，当观察到截止值约为 2.0μg/L 时，风险呈平台状。当在贝叶斯核机器回归（BKMR）模型中考虑其他必需元素时，钼与 MetS 的剂量依赖性关系仍然一致。在我们的研究中，较高的血浆钼水平与 MetS 及其各组分呈显著的剂量反应关系，MetS 风险降低。
