Smith J C, Mitzner W
J Appl Physiol Respir Environ Exerc Physiol. 1983 Jun;54(6):1717-25. doi: 10.1152/jappl.1983.54.6.1717.
An analysis of the elastic behavior of the lung perivascular interstitial space during interstitial fluid accumulation is presented. Fluid accumulation must deform the lung parenchyma and vascular walls that form the interstitial space boundaries. The deformations of these boundaries are predicted from previously published data on the elastic properties of the boundary materials. The analysis gives the relationships among the elastic properties of the boundaries, the compliance of the interstitium, the lung volume, and the lung elastic recoil pressure. Values of the interstitial compliance are predicted to decrease with increasing lung recoil pressure and are dependent on the lung pressure-volume history. At low recoil pressures over 70% of the interstitial compliance results from deformation of the parenchyma. As the recoil pressure increases, either with increasing lung volume or due to the lung pressure-volume history, the contributions of the parenchymal and vascular wall deformations become similar. The predictions are generally consistent with published data on interstitial compliance obtained from measurements of isolated lung weight gain during vascular fluid transudation. This correlation suggests that the elastic behavior of the interstitial space can be accounted for by the known elastic properties of the boundary materials.
本文对间质液积聚期间肺血管周围间质空间的弹性行为进行了分析。液体积聚必然会使构成间质空间边界的肺实质和血管壁发生变形。这些边界的变形是根据先前发表的关于边界材料弹性特性的数据预测得出的。该分析给出了边界的弹性特性、间质顺应性、肺容积和肺弹性回缩压力之间的关系。预计间质顺应性值会随着肺回缩压力的增加而降低，并且取决于肺压力-容积历史。在低回缩压力下，超过70%的间质顺应性源于实质的变形。随着回缩压力的增加，无论是随着肺容积的增加还是由于肺压力-容积历史的原因，实质和血管壁变形的贡献变得相似。这些预测总体上与通过血管内液体渗出期间测量离体肺重量增加所获得的关于间质顺应性的已发表数据一致。这种相关性表明，间质空间的弹性行为可以由边界材料已知的弹性特性来解释。
