Departments of Anesthesiology.
Departments of Psychology.
Clin J Pain. 2020 Dec;36(12):897-906. doi: 10.1097/AJP.0000000000000882.
Prior work in a cohort of youth with functional abdominal pain (FAP) identified patient subgroups (High Pain Dysfunctional, High Pain Adaptive, Low Pain Adaptive) that predicted differences in the course of FAP from childhood into young adulthood. We aimed to replicate these subgroups in a new sample of adolescents with FAP using the original classification algorithm and to extend subgroup characteristics to include parental characteristics and health service use.
Adolescents (n=278; ages 11 to 17 y, 66% females) presenting to a gastroenterology clinic for abdominal pain, and their parents (92% mothers) completed self-report measures; adolescents also completed a 7-day pain diary.
The replicated patient subgroups exhibited distress and impairment similar to subgroups in the original sample. Moreover, in novel findings, the High Pain Dysfunctional subgroup differed from other subgroups by the predominance of mother-daughter dyads jointly characterized by high levels of anxiety, depressive symptoms, pain behavior, and pain catastrophizing. The High Pain Dysfunctional subgroup used more health care services than Low Pain Adaptive but did not differ from High Pain Adaptive.
Findings replicate and extend the original FAP classification and suggest that the subgroups have unique patient and parent features that may reflect distinct illness mechanisms requiring different treatments.
先前对功能性腹痛(FAP)患者队列的研究确定了患者亚组(高疼痛功能障碍、高疼痛适应性、低疼痛适应性),这些亚组预测了 FAP 从儿童期到青年期的病程差异。我们旨在使用原始分类算法在新的 FAP 青少年样本中复制这些亚组,并将亚组特征扩展到包括父母特征和卫生服务利用。
患有腹痛的青少年(n=278;年龄 11 至 17 岁,66%为女性)及其父母(92%为母亲)完成了自我报告量表;青少年还完成了 7 天疼痛日记。
复制的患者亚组表现出与原始样本中亚组相似的痛苦和功能障碍。此外,在新的发现中,高疼痛功能障碍亚组与其他亚组的不同之处在于,母女对子共同表现出高水平的焦虑、抑郁症状、疼痛行为和疼痛灾难化。高疼痛功能障碍亚组比低疼痛适应性亚组使用更多的医疗保健服务,但与高疼痛适应性亚组无差异。
研究结果复制并扩展了原始的 FAP 分类,并表明这些亚组具有独特的患者和父母特征,可能反映了不同的疾病机制,需要不同的治疗方法。