Department of Clinical and Health Psychology, University of Florida, P.O. Box 100165, Gainesville, FL, 32610-0165, USA.
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
BMC Res Notes. 2021 Sep 15;14(1):360. doi: 10.1186/s13104-021-05776-5.
Children with functional abdominal pain disorders (FAPD) and clinical elevations in three risk areas (anxiety, functional disability, and pain) have been found to be at increased risk for persistent disability. We evaluated if the presence of these three risk factors corresponded with greater gastrointestinal inflammation (measured via fecal calprotectin; FC) compared to those with no risk factors. FC concentration differences between children with three risk factors and those with one and two risk factors were explored.
Fifty-six children with FAPD (M = 12.23) completed measures of anxiety (Screen for Child Anxiety Related Disorders), disability (Functional Disability Inventory), and pain intensity (Numeric Rating Scale). Participants were stratified into risk groups (range: 0-3). Fisher's exact tests were conducted to determine if children with three versus fewer risk factors were more likely to have elevated FC (≥ 50 µg/g) versus normal levels. Children with three risk factors (M = 86.04) were more likely to have elevated FC compared to children with zero (M = 25.78), one (M = 38.59), and two risk factors (M = 45.06; p's < 0.05). Those with three risk factors had borderline elevated FC concentrations whereas those with fewer had normal FC concentrations. Findings suggest the importance of a biopsychosocial approach to help elucidate a FAPD phenotype.
研究发现，功能性腹痛障碍（FAPD）患儿和具有三个风险因素（焦虑、功能障碍和疼痛）的临床升高的患儿持续性残疾的风险增加。我们评估了这些三个风险因素的存在是否与更高的胃肠道炎症（通过粪便钙卫蛋白；FC）相关，与没有风险因素的患儿相比。探讨了具有三个风险因素的患儿与具有一个和两个风险因素的患儿之间 FC 浓度的差异。
56 名 FAPD 患儿（M = 12.23）完成了焦虑（儿童焦虑相关障碍筛查）、残疾（功能障碍量表）和疼痛强度（数字评分量表）的测量。参与者分为风险组（范围：0-3）。进行 Fisher 确切检验以确定具有三个风险因素与少于三个风险因素的患儿更有可能出现 FC 升高（≥ 50 µg/g）与正常水平。具有三个风险因素的患儿（M = 86.04）比没有风险因素的患儿（M = 25.78）、有一个风险因素的患儿（M = 38.59）和有两个风险因素的患儿（M = 45.06）更有可能出现 FC 升高（p's < 0.05）。具有三个风险因素的患儿的 FC 浓度有边界升高，而具有较少风险因素的患儿的 FC 浓度正常。这些发现表明，采用生物心理社会方法来帮助阐明 FAPD 表型的重要性。
