18F-FBPA PET 在结节病中的应用：与 FDG PET 上炎症相关摄取的比较。
18F-FBPA PET in Sarcoidosis: Comparison to Inflammation-Related Uptake on FDG PET.
机构信息
Department of Oral and Maxillofacial Radiology, Graduate School of Dentistry, Osaka University.
Department of Radiology, Osaka University Hospital, Osaka University, Suita, Japan.
出版信息
Clin Nucl Med. 2020 Nov;45(11):863-864. doi: 10.1097/RLU.0000000000003274.
A 68-year-old man with sarcoidosis showed high F-FDG uptake in the mediastinal and hilar lymph nodes on F-FDG PET, suggesting active inflammation. F-fluoro-boronophenylalanine (FBPA) PET showed no significant uptake in the mediastinal and hilar lymph nodes, suggesting its cancer specificity as a substrate of L-type amino acid transporter 1. F-fluoro-boronophenylalanine PET can be used for precise evaluation in oncology when the differentiation between inflammation and metastasis is inconclusive on F-FDG PET.
一位 68 岁的结节病患者在 F-FDG PET 上显示纵隔和肺门淋巴结摄取 F-FDG 增加，提示存在活动性炎症。F-氟代苯丙氨酸（FBPA）PET 显示纵隔和肺门淋巴结摄取无明显增加，提示其作为 L 型氨基酸转运体 1 的底物具有肿瘤特异性。当 F-FDG PET 对炎症和转移的区分不明确时，F-氟代苯丙氨酸 PET 可用于肿瘤的精确评估。
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