Key Laboratory of Ministry of Education for Subtropical Wetland Ecosystem Research, School of Life Sciences, Xiamen University, Xiangan South Road, Xiamen, 361002, Fujian, China.
State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, 361002, Fujian, China.
Environ Sci Pollut Res Int. 2020 Dec;27(35):43599-43614. doi: 10.1007/s11356-020-10800-5. Epub 2020 Sep 24.
In the past decades, the type of chemicals has gradually increased all over the world, and many of these chemicals may have a potentially toxic effect on human health. The zebrafish, as an excellent vertebrate model, is increasingly used for assessing chemical toxicity and safety. This review summarizes the efficacy of zebrafish as a model for the study of developmental toxicity, reproductive toxicity, cardiovascular toxicity, neurodevelopmental toxicity, and ocular developmental toxicity of hazardous chemicals, and the transgenic zebrafish as biosensors are used to detect the environmental pollutants.
在过去几十年中，全世界化学物质的种类逐渐增加，其中许多化学物质可能对人类健康产生潜在的毒性影响。斑马鱼作为一种优秀的脊椎动物模型，越来越多地被用于评估化学物质的毒性和安全性。本文综述了斑马鱼作为研究危险化学物质发育毒性、生殖毒性、心血管毒性、神经发育毒性和眼发育毒性的模型的功效，以及作为生物传感器的转基因斑马鱼用于检测环境污染物的应用。
