Department of Kidney Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China.
Department of Pathological Cell Biology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
J Leukoc Biol. 2021 Feb;109(2):407-413. doi: 10.1002/JLB.4MR0820-011R. Epub 2020 Sep 24.
Neutrophils, which are traditionally regarded as a hallmark of inflammation, are also a member of the intratumoral immune cells. The roles of neutrophils in cancer development are diverse and undefined. So far, they are known to be involved in tumor initiation and tumor cell proliferation and metastasis. They show heterogeneity in both phenotypes and functions during early versus late stage of cancer development. Because they are also associated with the clinical outcomes of various types of solid tumors, cancer treatments that target neutrophils might be highly effective. In this review, we briefly cover the latest findings on the multiple roles of neutrophils in cancer development and point out the future directions as well.
中性粒细胞，传统上被认为是炎症的标志，也是肿瘤内免疫细胞的一员。中性粒细胞在癌症发展中的作用是多样化的，目前还没有明确的定义。到目前为止，它们被认为参与肿瘤的起始、肿瘤细胞的增殖和转移。在癌症发展的早期和晚期，它们在表型和功能上表现出异质性。由于它们也与各种实体瘤的临床结局相关，针对中性粒细胞的癌症治疗可能非常有效。在这篇综述中，我们简要介绍了中性粒细胞在癌症发展中的多种作用的最新发现，并指出了未来的方向。
