对达托霉素耐药的粪肠球菌在liaX基因上发生了突变，该基因编码一种表面蛋白，可抑制LiaFSR系统和细胞膜重塑。
Daptomycin resistant Enterococcus faecalis has a mutation in liaX, which encodes a surface protein that inhibits the LiaFSR systems and cell membrane remodeling.
作者信息
Ota Yusuke, Furuhashi Kazuki, Hayashi Wataru, Hirai Nachi, Ishikawa Jinko, Nagura Osanori, Yamanaka Katsumasa, Katahashi Kazuto, Aoki Kotaro, Nagano Noriyuki, Maekawa Masato
机构信息
Department of Laboratory Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
Department of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, Nagano, Japan.
出版信息
J Infect Chemother. 2021 Jan;27(1):90-93. doi: 10.1016/j.jiac.2020.09.004. Epub 2020 Sep 22.
The emergence of daptomycin (DAP) resistant Enterococcus species has increased worldwide, but the mechanisms for DAP resistance are not fully understood. We report a case of DAP resistant Enterococcus faecalis, from a clinical sample of a patient with diabetic ulcers, after DAP therapy. Whole-genome sequencing analysis revealed that the isolate had a loss-of-function point mutation within liaX encoding DAP-sensing surface protein, which inhibits the LiaFSR systems and cell membrane remodeling. This is the first case report of a clinical DAP resistant E. faecalis with a mutation in liaX.
达托霉素（DAP）耐药肠球菌在全球范围内的出现有所增加，但DAP耐药机制尚未完全明确。我们报告了1例在接受DAP治疗后，从1例糖尿病溃疡患者的临床样本中分离出的耐DAP粪肠球菌病例。全基因组测序分析显示，该分离株在编码DAP感应表面蛋白的liaX基因内存在功能丧失性点突变，该突变抑制了LiaFSR系统和细胞膜重塑。这是首例关于liaX基因发生突变的临床耐DAP粪肠球菌病例报告。
Zotero 插件