Samaddar Arghadip, Srivastava Saumya, Khan Salman, Tak Vibhor, Sharma Anuradha, Nag Vijaya Lakshmi, Bohra Gopal Krishna
Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Department of General Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Access Microbiol. 2019 Oct 21;1(10):e000069. doi: 10.1099/acmi.0.000069. eCollection 2019.
Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms found in soil and water. Infections caused by NTM are increasing with conditions ranging from harmless colonization to invasive infections, the latter being more common in immunocompromised hosts. In this report, we present a case of bacteraemia caused by , a rapidly growing NTM belonging to Class IV in the Runyon classification, in a 71-year-old male with ocular myasthenia gravis undergoing treatment with oral prednisolone. Gram staining of these organisms from blood culture can be easily overlooked or confused with diptheroids. Detection of Gram-positive bacilli should prompt Ziehl-Neelsen staining to distinguish diphtheroids from rapidly growing mycobacteria in immunosuppressed patients. In addition, speciation and antimicrobial susceptibility testing are of paramount importance in such cases as there is considerable variation in the resistance patterns between different species of NTM. Line probe assay provides a rapid and reliable method for identification of NTM to the species level, which can guide treatment with appropriate antibiotics. This case report highlights the importance of early detection of such cases so as to optimize management and improve patient outcomes.
非结核分枝杆菌(NTM)是存在于土壤和水中的普遍环境生物。NTM引起的感染正在增加,其情况从无害定植到侵袭性感染不等,后者在免疫功能低下的宿主中更为常见。在本报告中,我们介绍了一例由 引起的菌血症病例, 是Runyon分类中IV类的快速生长NTM,患者为一名71岁患有眼肌型重症肌无力的男性,正在接受口服泼尼松龙治疗。血培养中这些微生物的革兰氏染色很容易被忽视或与类白喉杆菌混淆。在免疫抑制患者中,检测到革兰氏阳性杆菌应促使进行齐-尼氏染色,以区分类白喉杆菌和快速生长的分枝杆菌。此外,在这种情况下,菌种鉴定和抗菌药敏试验至关重要,因为不同种类的NTM之间的耐药模式存在很大差异。线性探针分析提供了一种快速可靠的方法,可将NTM鉴定到种水平,从而指导使用适当的抗生素进行治疗。本病例报告强调了早期发现此类病例的重要性,以便优化管理并改善患者预后。 (注:原文中“caused by ”处缺失具体菌种名称)