• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一名接受长期类固醇治疗的重症肌无力患者发生菌血症。

bacteraemia in a patient with myasthenia gravis receiving long-term steroid therapy.

作者信息

Samaddar Arghadip, Srivastava Saumya, Khan Salman, Tak Vibhor, Sharma Anuradha, Nag Vijaya Lakshmi, Bohra Gopal Krishna

机构信息

Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Department of General Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

出版信息

Access Microbiol. 2019 Oct 21;1(10):e000069. doi: 10.1099/acmi.0.000069. eCollection 2019.

DOI:10.1099/acmi.0.000069
PMID:32974503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7491934/
Abstract

Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms found in soil and water. Infections caused by NTM are increasing with conditions ranging from harmless colonization to invasive infections, the latter being more common in immunocompromised hosts. In this report, we present a case of bacteraemia caused by , a rapidly growing NTM belonging to Class IV in the Runyon classification, in a 71-year-old male with ocular myasthenia gravis undergoing treatment with oral prednisolone. Gram staining of these organisms from blood culture can be easily overlooked or confused with diptheroids. Detection of Gram-positive bacilli should prompt Ziehl-Neelsen staining to distinguish diphtheroids from rapidly growing mycobacteria in immunosuppressed patients. In addition, speciation and antimicrobial susceptibility testing are of paramount importance in such cases as there is considerable variation in the resistance patterns between different species of NTM. Line probe assay provides a rapid and reliable method for identification of NTM to the species level, which can guide treatment with appropriate antibiotics. This case report highlights the importance of early detection of such cases so as to optimize management and improve patient outcomes.

摘要

非结核分枝杆菌(NTM)是存在于土壤和水中的普遍环境生物。NTM引起的感染正在增加,其情况从无害定植到侵袭性感染不等,后者在免疫功能低下的宿主中更为常见。在本报告中,我们介绍了一例由 引起的菌血症病例, 是Runyon分类中IV类的快速生长NTM,患者为一名71岁患有眼肌型重症肌无力的男性,正在接受口服泼尼松龙治疗。血培养中这些微生物的革兰氏染色很容易被忽视或与类白喉杆菌混淆。在免疫抑制患者中,检测到革兰氏阳性杆菌应促使进行齐-尼氏染色,以区分类白喉杆菌和快速生长的分枝杆菌。此外,在这种情况下,菌种鉴定和抗菌药敏试验至关重要,因为不同种类的NTM之间的耐药模式存在很大差异。线性探针分析提供了一种快速可靠的方法,可将NTM鉴定到种水平,从而指导使用适当的抗生素进行治疗。本病例报告强调了早期发现此类病例的重要性,以便优化管理并改善患者预后。 (注:原文中“caused by ”处缺失具体菌种名称)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ca5/7491934/c96b453729ff/acmi-1-069-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ca5/7491934/a5713247cb47/acmi-1-069-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ca5/7491934/c889524094d9/acmi-1-069-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ca5/7491934/34af424b6e67/acmi-1-069-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ca5/7491934/c96b453729ff/acmi-1-069-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ca5/7491934/a5713247cb47/acmi-1-069-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ca5/7491934/c889524094d9/acmi-1-069-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ca5/7491934/34af424b6e67/acmi-1-069-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ca5/7491934/c96b453729ff/acmi-1-069-g004.jpg

相似文献

1
bacteraemia in a patient with myasthenia gravis receiving long-term steroid therapy.一名接受长期类固醇治疗的重症肌无力患者发生菌血症。
Access Microbiol. 2019 Oct 21;1(10):e000069. doi: 10.1099/acmi.0.000069. eCollection 2019.
2
Mycobacterium chelonae complex bacteremia from a post-renal transplant patient: case report and literature review.龟分枝杆菌复合群菌血症致肾移植术后患者:病例报告及文献复习。
Jpn J Infect Dis. 2010 Jan;63(1):61-4.
3
cutaneous infection: An opportunistic disease in an immunosuppressed patient with myasthenia gravis.皮肤感染:重症肌无力免疫抑制患者的一种机会性疾病。
IDCases. 2020 May 13;21:e00817. doi: 10.1016/j.idcr.2020.e00817. eCollection 2020.
4
Infections caused by non-tuberculous mycobacteria in recipients of hematopoietic stem cell transplantation.造血干细胞移植受者中非结核分枝杆菌感染。
Front Oncol. 2014 Nov 10;4:311. doi: 10.3389/fonc.2014.00311. eCollection 2014.
5
Non-Tuberculosis mycobacterium speciation using HPLC under Revised National TB Control Programme (RNTCP) in India.采用 HPLC 对印度修订国家结核病控制规划(RNTCP)中的非结核分枝杆菌进行种属鉴定。
J Appl Microbiol. 2018 Jan;124(1):267-273. doi: 10.1111/jam.13604. Epub 2017 Nov 23.
6
Identification of Non-Tuberculosis Mycobacteria by Line Probe Assay and Determination of Drug Resistance Patterns of Isolates in Iranian Patients.应用线性探针分析法鉴定非结核分枝杆菌并确定伊朗患者分离株的耐药模式
Arch Razi Inst. 2019 Dec;74(4):375-384. doi: 10.22092/ari.2019.127144.1372. Epub 2019 Dec 1.
7
[Identification and isolation of non-tuberculous mycobacteria from environmental samples].[从环境样本中鉴定和分离非结核分枝杆菌]
Mikrobiyol Bul. 2010 Jul;44(3):395-403.
8
Delayed post-operative wound infections due to non-tuberculous Mycobacterium.非结核分枝杆菌引起的术后伤口延迟感染。
Indian J Med Res. 2005 Dec;122(6):535-9.
9
[Evaluation of the distribution of non-tuberculous mycobacteria strains isolated in National Tuberculosis Reference Laboratory in 2009-2010, Turkey].[2009 - 2010年土耳其国家结核病参考实验室分离的非结核分枝杆菌菌株分布评估]
Mikrobiyol Bul. 2012 Oct;46(4):560-7.
10
[Cutaneous and soft skin infections due to non-tuberculous mycobacteria].非结核分枝杆菌引起的皮肤及软组织感染
Enferm Infecc Microbiol Clin. 2010 Jan;28 Suppl 1:46-50. doi: 10.1016/S0213-005X(10)70008-2.

引用本文的文献

1
Mycobacterium marseillense bloodstream infection combined with skin fungal infection: a case report and literature review.马赛分枝杆菌血流感染合并皮肤真菌感染:一例病例报告并文献复习。
BMC Infect Dis. 2024 Aug 22;24(1):853. doi: 10.1186/s12879-024-09741-y.

本文引用的文献

1
Current significance of the Mycobacterium chelonae-abscessus group.龟分枝杆菌-脓肿分枝杆菌群的当前意义。
Diagn Microbiol Infect Dis. 2019 Jul;94(3):248-254. doi: 10.1016/j.diagmicrobio.2019.01.021. Epub 2019 Feb 10.
2
Increasing nontuberculous mycobacteria reporting rates and species diversity identified in clinical laboratory reports.提高临床实验室报告中报告的非结核分枝杆菌的检出率和物种多样性。
BMC Infect Dis. 2018 Apr 10;18(1):163. doi: 10.1186/s12879-018-3043-7.
3
Mycobacterium chelonae Is an Ubiquitous Atypical Mycobacterium.
龟分枝杆菌是一种广泛存在的非典型分枝杆菌。
Case Rep Dermatol. 2015 Aug 12;7(2):207-11. doi: 10.1159/000438898. eCollection 2015 May-Aug.
4
Role of GenoType(®) Mycobacterium Common Mycobacteria/Additional Species Assay for Rapid Differentiation Between Mycobacterium tuberculosis Complex and Different Species of Non-Tuberculous Mycobacteria.基因分型(®)检测对常见分枝杆菌/其他分枝杆菌种类在结核分枝杆菌复合群与不同种类非结核分枝杆菌之间进行快速鉴别中的作用
J Lab Physicians. 2013 Jul;5(2):83-9. doi: 10.4103/0974-2727.119847.
5
Comparative drug resistance of Mycobacterium abscessus and M. chelonae isolates from patients with and without cystic fibrosis in the United Kingdom.英国囊性纤维化患者与非囊性纤维化患者分枝杆菌脓肿和分枝杆菌龟亚种分离株的药物耐药性比较。
J Clin Microbiol. 2013 Jan;51(1):217-23. doi: 10.1128/JCM.02260-12. Epub 2012 Nov 7.
6
Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.非结核分枝杆菌感染的抗菌药物敏感性试验、耐药机制及治疗。
Clin Microbiol Rev. 2012 Jul;25(3):545-82. doi: 10.1128/CMR.05030-11.
7
The neglected and often ignored: nontuberculous mycobacteria.被忽视且常被忽略的:非结核分枝杆菌。
J Glob Infect Dis. 2011 Jan;3(1):94. doi: 10.4103/0974-777X.77305.
8
Rapidly growing mycobacteria infection in patients with cancer.快速生长分枝杆菌感染的癌症患者。
Clin Infect Dis. 2010 Aug 15;51(4):422-34. doi: 10.1086/655140.
9
Mycobacterium chelonae complex bacteremia from a post-renal transplant patient: case report and literature review.龟分枝杆菌复合群菌血症致肾移植术后患者:病例报告及文献复习。
Jpn J Infect Dis. 2010 Jan;63(1):61-4.
10
An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases.美国胸科学会/美国感染病学会官方声明:非结核分枝杆菌病的诊断、治疗与预防
Am J Respir Crit Care Med. 2007 Feb 15;175(4):367-416. doi: 10.1164/rccm.200604-571ST.