Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, India.
J Membr Biol. 2020 Oct;253(5):459-468. doi: 10.1007/s00232-020-00139-w. Epub 2020 Sep 25.
Copper is crucial for carrying out normal physiological functions in all higher life forms. Copper Transporter 1 (CTR1) is the high-affinity copper importer found in all eukaryotic organisms. The copper transporter family primarily comprises ~ six members (CTR1-6) and the related members share high sequence homology with CTR. However, with the exception of CTR1, not all six CTRs are present in every organism. Despite having a simple trimeric channel structure, CTR1 and other members exhibit some unique regulatory properties. In the present review, we attempt to understand the diversity and similarity of regulation and functioning of the members of this copper transporter family.
铜对于所有高等生命形式的正常生理功能至关重要。铜转运蛋白 1（CTR1）是所有真核生物中发现的高亲和力铜进口器。铜转运蛋白家族主要包括约 6 个成员（CTR1-6），与 CTR 相关的成员具有高度的序列同源性。然而，除了 CTR1 之外，并非所有 6 个 CTR 都存在于每个生物体中。尽管具有简单的三聚体通道结构，但 CTR1 和其他成员表现出一些独特的调节特性。在本综述中，我们试图理解这个铜转运蛋白家族成员的调节和功能的多样性和相似性。
