Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Int J Mol Sci. 2020 Sep 23;21(19):6979. doi: 10.3390/ijms21196979.
Tuberculosis (TB) is a major public health concern for all ages. However, the disease presents a larger challenge in pediatric populations, partially owing to the lack of reliable diagnostic standards for the early identification of infection. Currently, there are no biomarkers that have been clinically validated for use in pediatric TB diagnosis. Identification and validation of biomarkers could provide critical information on prognosis of disease, and response to treatment. In this review, we discuss how the "omics" approach has influenced biomarker discovery and the advancement of a next generation rapid point-of-care diagnostic for TB, with special emphasis on pediatric disease. Limitations of current published studies and the barriers to their implementation into the field will be thoroughly reviewed within this article in hopes of highlighting future avenues and needs for combating the problem of pediatric tuberculosis.
结核病（TB）是全年龄段的主要公共卫生关注点。然而，由于缺乏可靠的诊断标准来早期识别感染，该疾病在儿科人群中构成了更大的挑战。目前，尚无经过临床验证可用于儿科结核病诊断的生物标志物。生物标志物的识别和验证可以提供关于疾病预后和治疗反应的关键信息。在这篇综述中，我们讨论了“组学”方法如何影响生物标志物的发现以及下一代快速即时诊断 TB 的进展，特别强调了儿科疾病。本文将深入讨论当前已发表研究的局限性及其在该领域实施的障碍，以期突出未来解决儿科结核病问题的途径和需求。
