Dzau V J, Brody T, Ellison K E, Pratt R E, Ingelfinger J R
Hypertension. 1987 Jun;9(6 Pt 2):III36-41. doi: 10.1161/01.hyp.9.6_pt_2.iii36.
Increasing biochemical evidence suggests that the renin-angiotensin system may be present in may extrarenal tissues. We have employed the mouse submandibular gland renin complementary DNA (pDD-1D2) and the rat liver angiotensinogen complementary DNA (pRang 3) to demonstrate that renin and angiotensinogen messenger RNAs are expressed in the mouse kidney, submandibular gland, heart, adrenal, brain, and testis. To elucidate the factors that influence local tissue renin-angiotensin expressions, we studied tissue renin messenger RNA and enzymatic levels of male mice in response to sodium depletion and castration. Sodium depletion resulted in increased renin expression in the kidney, heart, and adrenal, but not in the submandibular gland and testis. Castration lowered renin levels in all extrarenal tissues but appeared to increase renin level in the kidney. Taken together, the above data demonstrate tissue-specific regulation of renin expression and imply different functions for the sodium responsive and nonresponsive systems.
越来越多的生物化学证据表明，肾素 - 血管紧张素系统可能存在于许多肾外组织中。我们利用小鼠颌下腺肾素互补DNA（pDD - 1D2）和大鼠肝脏血管紧张素原互补DNA（pRang 3）来证明肾素和血管紧张素原信使RNA在小鼠肾脏、颌下腺、心脏、肾上腺、脑和睾丸中表达。为了阐明影响局部组织肾素 - 血管紧张素表达的因素，我们研究了雄性小鼠在钠缺乏和去势情况下组织肾素信使RNA水平和酶活性。钠缺乏导致肾脏、心脏和肾上腺中肾素表达增加，但颌下腺和睾丸中没有增加。去势降低了所有肾外组织中的肾素水平，但似乎增加了肾脏中的肾素水平。综上所述，上述数据表明肾素表达存在组织特异性调节，并暗示钠反应性和非反应性系统具有不同功能。
