基于内镜检查的与中性粒细胞活性病理形态相关的胃炎京都分类评分
Endoscopy-based Kyoto classification score of gastritis related to pathological topography of neutrophil activity.
作者信息
Toyoshima Osamu, Nishizawa Toshihiro, Yoshida Shuntaro, Sakaguchi Yoshiki, Nakai Yousuke, Watanabe Hidenobu, Suzuki Hidekazu, Tanikawa Chizu, Matsuda Koichi, Koike Kazuhiko
机构信息
Department of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan.
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
出版信息
World J Gastroenterol. 2020 Sep 14;26(34):5146-5155. doi: 10.3748/wjg.v26.i34.5146.
BACKGROUND
Endoscopy-based Kyoto classification for gastritis and pathological topographic distribution of neutrophil infiltration are correlated with gastric cancer risk.
AIM
To investigate the association between Kyoto classification and the topographic distribution of neutrophil activity.
METHODS
Kyoto classification score, ranging from 0 to 8, consisted of atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness. Neutrophil activity was scored according to the updated Sydney System using biopsy samples obtained from the greater curvature of the corpus and the antrum. The participants were divided into four categories, inactive stomach, antrum-predominant gastritis, pangastritis, and corpus-predominant gastritis, based on the topographic distribution of neutrophil activity. Effects of sex, age, body mass index, drinking habit, smoking habit, family history of gastric cancer, serum () antibody, and Kyoto score on topography of neutrophil infiltration were analyzed.
RESULTS
A total of 327 patients (comprising 50.7% women, with an average age of 50.2 years) were enrolled in this study. infection rate was 82.9% with a mean Kyoto score of 4.63. The Kyoto score was associated with the topographic distribution of neutrophil activity. Kyoto scores were significantly higher in the order of inactive stomach, antrum-predominant gastritis, pangastritis, and corpus-predominant gastritis (3.05, 4.57, 5.21, and 5.96, respectively). Each individual score of endoscopic findings (., atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness) was correlated with the topographic distribution of neutrophil activity. On multivariate analysis, the Kyoto score, age, and serum antibody were independently associated with the topographic distribution of neutrophil activity.
CONCLUSION
The Kyoto classification score was associated with the topographic distribution of neutrophil activity.
背景
基于内镜检查的胃炎京都分类以及中性粒细胞浸润的病理地形分布与胃癌风险相关。
目的
研究京都分类与中性粒细胞活性地形分布之间的关联。
方法
京都分类评分范围为0至8分，包括萎缩、肠化生、皱襞粗大、结节和弥漫性发红。根据更新的悉尼系统，使用从胃体大弯和胃窦获取的活检样本对中性粒细胞活性进行评分。根据中性粒细胞活性的地形分布，将参与者分为四类：非活动性胃、胃窦为主型胃炎、全胃炎和胃体为主型胃炎。分析性别、年龄、体重指数、饮酒习惯、吸烟习惯、胃癌家族史、血清（）抗体和京都评分对中性粒细胞浸润地形的影响。
结果
本研究共纳入327例患者（女性占50.7%，平均年龄50.2岁）。感染率为82.9%，平均京都评分为4.63分。京都评分与中性粒细胞活性的地形分布相关。京都评分在非活动性胃、胃窦为主型胃炎、全胃炎和胃体为主型胃炎中依次显著升高（分别为3.05、4.57、5.21和5.96）。内镜检查结果的各项评分（如萎缩、肠化生、皱襞粗大、结节和弥漫性发红）均与中性粒细胞活性的地形分布相关。多因素分析显示，京都评分、年龄和血清抗体与中性粒细胞活性的地形分布独立相关。
结论
京都分类评分与中性粒细胞活性的地形分布相关。
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