Hovanesian John, Epitropoulos Alice, Donnenfeld Eric D, Holladay Jack T
Harvard Eye Associates, Laguna Hills, CA, USA.
Ophthalmic Surgeons & Consultants of Ohio, Columbus, OH, USA.
Clin Ophthalmol. 2020 Sep 16;14:2709-2716. doi: 10.2147/OPTH.S264520. eCollection 2020.
To determine the effect of lifitegrast ophthalmic solution 5% on improving the tear film, biometry/keratometry, and refractive accuracy for dry eye patients scheduled for cataract surgery.
Multicenter, prospective, open-label study of 100 eyes of 100 patients undergoing cataract surgery who had a confirmed diagnosis of dry eye. Patients underwent biometry at baseline and again after a 28-day course of lifitegrast 5% BID. Primary outcome was an improvement in the accuracy of preoperative anterior corneal power measurements at predicting postoperative spherical equivalent (SE) pre- and post-lifitegrast treatment. Secondary outcomes included changes in dry eye symptoms and corneal staining.
The accuracy of the biometry readings for the achieved refractive SE: within 0.25 D in 47% and 50% of eyes before and after the initial lifitegrast treatment, respectively; within 0.5 D in 71% and 79% of eyes before and after the initial lifitegrast treatment; and within 0.75 D in 81% and 91% of eyes before and after the initial lifitegrast treatment (p < 0.04).
Lifitegrast 5% significantly improved preoperative corneal surface measurement accuracy in patients with confirmed dry eye who were scheduled for cataract surgery.
确定5%的lifitegrast眼药水对计划进行白内障手术的干眼患者泪膜、生物测量/角膜曲率测量及屈光准确性的改善效果。
对100例确诊为干眼且计划进行白内障手术的患者的100只眼睛进行多中心、前瞻性、开放标签研究。患者在基线时进行生物测量，在接受28天每日两次的5%lifitegrast治疗后再次进行生物测量。主要结局是在lifitegrast治疗前后，术前角膜前表面屈光力测量在预测术后等效球镜度（SE）方面的准确性提高。次要结局包括干眼症状和角膜染色的变化。
对于达到的屈光SE，生物测量读数的准确性：在初始lifitegrast治疗前，分别有47%和50%的眼睛在0.25 D以内；在初始lifitegrast治疗后，分别有71%和79%的眼睛在0.5 D以内；在初始lifitegrast治疗前，分别有81%和91%的眼睛在0.75 D以内（p < 0.04）。
5%的lifitegrast显著提高了计划进行白内障手术的确诊干眼患者术前角膜表面测量的准确性。
