Fang Yu-Hung, Hsieh Meng-Jer, Hung Ming-Szu, Lin Yu-Ching, Kuo Liang-Tseng, Lu Mong-Liang, Tzang Bor-Show, Chen Vincent Chin-Hung
Division of Thoracic Oncology, Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Department of Respiratory Therapy, College of Medicine, Chang Gung University, Chiayi, Taiwan.
Neuropsychiatr Dis Treat. 2020 Sep 17;16:2103-2109. doi: 10.2147/NDT.S265182. eCollection 2020.
Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) concentrations were reported to decrease in patients with advanced cancer. However, the clinical significance of DHEA and DHEAS concentrations in patients with NSCLC receiving chemotherapy (CT) has not been sufficiently documented.
To evaluate the correlation between mental health and hormone concentrations on patients with advanced non-small-cell lung cancer (NSCLC).
The present study was a cross-sectional analysis based on a self-reported psychological investigation. Salivary samples were collected from 22 patients with advanced NSCLC after CT and 17 healthy controls. The concentrations of DHEA, DHEAS, and cortisol were analyzed to investigate their associations with the results of self-reported questionnaires on psychological health.
Patients with advanced NSCLC exhibited significantly higher Patient Health Questionnaire (PHQ-9) and Startle, Physiological arousal, Anger, and Numbness-Chinese version (SPAN-C) scores, poorer health conditions, lower sleep quality, and more severe fatigue after CT than did healthy controls, and salivary concentrations of DHEA and DHEAS were significantly lower among patients after CT than among controls. DHEAS concentrations were negatively associated with depression scores (PHQ-9, r = -0.496, = 0.019) and fatigue scores (Brief Fatigue Inventory-Taiwan, r = -0.562, = 0.006).
Patients with advanced NSCLC after CT had lower DHEA and DHEAS concentrations than did controls. Lower DHEAS concentrations were associated with higher fatigue and depression scores.
据报道，晚期癌症患者体内的脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）浓度会降低。然而，接受化疗（CT）的非小细胞肺癌（NSCLC）患者体内DHEA和DHEAS浓度的临床意义尚未得到充分记录。
评估晚期非小细胞肺癌（NSCLC）患者心理健康与激素浓度之间的相关性。
本研究是一项基于自我报告的心理调查的横断面分析。收集了22例接受CT治疗后的晚期NSCLC患者和17名健康对照者的唾液样本。分析DHEA、DHEAS和皮质醇的浓度，以研究它们与心理健康自我报告问卷结果之间的关联。
与健康对照者相比，晚期NSCLC患者在接受CT治疗后表现出明显更高的患者健康问卷（PHQ-9）和惊吓、生理唤醒、愤怒和麻木中文版（SPAN-C）评分，健康状况更差，睡眠质量更低，疲劳更严重，且CT治疗后患者的唾液中DHEA和DHEAS浓度明显低于对照组。DHEAS浓度与抑郁评分（PHQ-9，r = -0.496，P = 0.019）和疲劳评分（简明疲劳量表-台湾版，r = -0.562，P = 0.006）呈负相关。
接受CT治疗后的晚期NSCLC患者的DHEA和DHEAS浓度低于对照组。较低的DHEAS浓度与较高的疲劳和抑郁评分相关。
