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一名患有血红蛋白SC病的老年患者系统性非创伤性脂肪栓塞综合征的神经功能恢复：病例报告

Neurologic recovery in systemic nontraumatic fat embolism syndrome in an elderly patient with hemoglobin SC disease: A case report.

作者信息

Ositelu Ayotunde, Urrutia-Argueta Samuel, Kapoor Rajat

机构信息

Department of Internal Medicine Indiana University School of Medicine Indianapolis IN USA.

Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Indiana University School of Medicine Indianapolis IN USA.

出版信息

Clin Case Rep. 2020 Jun 16;8(9):1816-1820. doi: 10.1002/ccr3.3023. eCollection 2020 Sep.

DOI:10.1002/ccr3.3023
PMID:32983503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7495744/
Abstract

Cerebral fat embolism syndrome is an under-recognized yet well-known complication of bone marrow necrosis occurring in patients with sickle cell disease. We highlight a case manifested by multisystem organ failure in an elderly patient who attained neurologic recovery with prompt initiation of hematology consultation, RBC exchange, and supportive measures.

摘要

脑脂肪栓塞综合征是镰状细胞病患者骨髓坏死中一种未被充分认识但广为人知的并发症。我们重点介绍了一例老年患者，该患者表现为多系统器官衰竭，通过及时启动血液学会诊、红细胞置换和支持措施实现了神经功能恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19fa/7495744/1cf81498d3d3/CCR3-8-1816-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19fa/7495744/1cf81498d3d3/CCR3-8-1816-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19fa/7495744/1cf81498d3d3/CCR3-8-1816-g001.jpg

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本文引用的文献

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Cerebral fat embolism in sickle cell disease.
Am J Hematol. 2020 Feb;95(2):E41-E45. doi: 10.1002/ajh.25686. Epub 2019 Nov 29.
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Extensive Bone Marrow Necrosis: Initial Presentation in Sickle Cell Anemia-A Case Report and Review of the Literature.广泛骨髓坏死：镰状细胞贫血的首次表现——病例报告及文献综述
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Successful outcome of three patients with sickle-cell disease and fat embolism syndrome treated with intensive exchange transfusion.3例镰状细胞病合并脂肪栓塞综合征患者经强化换血治疗取得成功结果。
因镰状细胞病导致的脑脂肪栓塞综合征引起的昏迷，在红细胞交换输血后完全恢复。
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Clin Case Rep. 2016 Dec 20;5(1):39-43. doi: 10.1002/ccr3.727. eCollection 2017 Jan.
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Cerebral fat embolism syndrome mimicking thrombotic thrombocytopenic purpura in a patient with hemoglobin SC disease.一名血红蛋白SC病患者出现酷似血栓性血小板减少性紫癜的脑脂肪栓塞综合征。
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Bone marrow necrosis and fat embolism syndrome in sickle cell disease: increased susceptibility of patients with non-SS genotypes and a possible association with human parvovirus B19 infection.镰状细胞病中的骨髓坏死和脂肪栓塞综合征：非 SS 基因型患者的易感性增加，且可能与人类细小病毒 B19 感染有关。
Blood Rev. 2014 Jan;28(1):23-30. doi: 10.1016/j.blre.2013.12.002. Epub 2014 Jan 11.
6
Necrosis of the bone marrow with fat embolism in sickle cell anemia.镰状细胞贫血伴脂肪栓塞的骨髓坏死。
Am J Pathol. 1941 Jan;17(1):47-54.5.
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Fat embolism syndrome.脂肪栓塞综合征
J Assoc Physicians India. 2008 Apr;56:245-9.
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