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广泛期小细胞肺癌伴大脑大转移灶经姑息性放疗后九年完全缓解病例：治愈是可能的。

Case of Complete Remission from Palliative Radiation in Extensive Stage Small Cell Lung Cancer With Large Brain Metastasis Nine Years After Diagnosis: Cure Is Possible.

作者信息

Pan Ming

机构信息

Radiation Oncology, Windsor Regional Hospital Cancer Program, Windsor, CAN.

出版信息

Cureus. 2020 Aug 25;12(8):e10011. doi: 10.7759/cureus.10011.

DOI:10.7759/cureus.10011
PMID:32983707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7515215/
Abstract

Extensive stage small cell lung cancer (ES-SCLC) with symptomatic brain metastasis (BM) carries very poor prognosis with a median survival of only three to four months. This case shows the potential benefit of offering aggressive multimodality treatment to achieve the best quality of life and to improve survival. A complete response (CR) was achieved following craniotomy, whole brain irradiation (WBI), palliative chemotherapy, and palliative consolidative thoracic radiotherapy (CTRT) for ES-SCLC with large symptomatic BM. There was no residual cancer or further metastasis seen on CT imaging. The patient remains cancer free and asymptomatic nine years after the initial diagnosis.

摘要

广泛期小细胞肺癌（ES-SCLC）伴症状性脑转移（BM）的预后极差，中位生存期仅为三到四个月。本病例显示了积极采用多模式治疗以实现最佳生活质量并提高生存率的潜在益处。对于伴有大型症状性BM的ES-SCLC患者，在开颅手术、全脑照射（WBI）、姑息性化疗和姑息性巩固性胸部放疗（CTRT）后实现了完全缓解（CR）。CT成像未发现残留癌症或进一步转移。患者在初次诊断九年后仍无癌症且无症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/a440cabfaea0/cureus-0012-00000010011-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/0c16e4f9604e/cureus-0012-00000010011-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/1f573eb173c5/cureus-0012-00000010011-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/9e0aca1e7bd3/cureus-0012-00000010011-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/c4f819d92adb/cureus-0012-00000010011-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/efa36b6123ff/cureus-0012-00000010011-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/2b6069e5aeed/cureus-0012-00000010011-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/a440cabfaea0/cureus-0012-00000010011-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/0c16e4f9604e/cureus-0012-00000010011-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/1f573eb173c5/cureus-0012-00000010011-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/9e0aca1e7bd3/cureus-0012-00000010011-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/c4f819d92adb/cureus-0012-00000010011-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/efa36b6123ff/cureus-0012-00000010011-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/2b6069e5aeed/cureus-0012-00000010011-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c42d/7515215/a440cabfaea0/cureus-0012-00000010011-i07.jpg

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