Kang Byeong Jin, Chung Jae Min, Lee Sang Don
Department of Urology, Pusan National University School of Medicine, Yangsan, Korea.
Department of Urology, Pusan National University Hospital, Busan, Korea.
Res Rep Urol. 2020 Sep 15;12:383-389. doi: 10.2147/RRU.S267417. eCollection 2020.
This study aimed to identify whether functional bladder capacity (FBC) differs among subgroups of nocturnal enuresis (NE) patients and can be used to predict treatment response.
A total of 69 children with NE were included in this study between July 2017 and February 2019 according to medical chart review, retrospectively. All patients completed a questionnaire about voiding symptoms and 48-hour frequency/volume (48-h F/V) charts. FBC was obtained from the 48-h F/V charts and uroflowmetry (UFM) with post-void residual volume (PVR). All patients were primarily treated with standard urotherapy and pharmacological therapy. The response rate was analyzed at 3 months after treatment.
The mean age of the 69 patients (42 male, 27 female) was 83.3 ± 22.4 months (range, 5-13 years) at the first visit. The percentages of children with monosymptomatic NE (MNE) and non-monosymptomatic NE (NMNE) on the questionnaire were 40.6% (28/69) and 59.4% (41/69), respectively. FBC of all patients was lower than the normal range of expected bladder capacity, and there were no significant differences between measurement methods, NE types (MNE vs NMNE), or response rates (p > 0.05).
Children with NE had diminished FBC in both 48-h F/V charts and UFM with PVR. We found no difference in FBC by NE type or treatment outcome. Therefore, FBC cannot be used to distinguish between NE types or predict treatment responses.
本研究旨在确定功能性膀胱容量（FBC）在夜间遗尿（NE）患者亚组中是否存在差异，以及是否可用于预测治疗反应。
通过回顾病历，2017年7月至2019年2月间共纳入69例NE患儿。所有患者均完成了一份关于排尿症状的问卷以及48小时频率/尿量（48-h F/V）图表。FBC通过48-h F/V图表以及结合排尿后残余尿量（PVR）的尿流率测定（UFM）获得。所有患者均首先接受标准的尿疗法和药物治疗。治疗3个月后分析反应率。
69例患者（42例男性，27例女性）首次就诊时的平均年龄为83.3±22.4个月（范围5 - 13岁）。问卷中单纯症状性NE（MNE）和非单纯症状性NE（NMNE）患儿的比例分别为40.6%（28/69）和59.4%（41/69）。所有患者的FBC均低于预期膀胱容量的正常范围，测量方法、NE类型（MNE与NMNE）或反应率之间均无显著差异（p>0.05）。
NE患儿在48-h F/V图表以及结合PVR的UFM中FBC均降低。我们发现不同NE类型或治疗结果的FBC无差异。因此，FBC不能用于区分NE类型或预测治疗反应。
