逆转录病毒介导的基因转移后人类腺苷脱氨酶在非人类灵长类动物中的表达。
Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer.
作者信息
Kantoff P W, Gillio A P, McLachlin J R, Bordignon C, Eglitis M A, Kernan N A, Moen R C, Kohn D B, Yu S F, Karson E
出版信息
J Exp Med. 1987 Jul 1;166(1):219-34. doi: 10.1084/jem.166.1.219.
Abstract
Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time.
摘要
灵长类动物骨髓细胞被携带人类腺苷脱氨酶（h-ADA）基因和细菌新霉素抗性（neor）基因的逆转录病毒载体感染。将感染后的细胞回输到接受致死剂量照射的供体动物体内。几只猴子实现了完全重建，并被证明在短时间内其循环造血细胞中低水平表达h-ADA和neor基因。
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