Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara , Chieti, Italy.
Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, University of Milan , Milan, Italy.
Expert Opin Ther Pat. 2020 Dec;30(12):917-930. doi: 10.1080/13543776.2020.1830059. Epub 2020 Oct 10.
Biofilm is a complex aggregation of microorganisms characterized by the presence of a dynamic, adhesive and protective extracellular matrix composed of polysaccharides, proteins and nucleic acids. It is estimated that the vast majority of human infections are related to the biofilm in which the microorganisms reside and communicate with each other (Quorum Sensing), surviving in hostile environmental conditions.
This review provides a comprehensive focus on the development state of promising strategies against biofilm production and eradication describing chemical structures, results, administration routes, pharmaceutical compositions, and SARs as well as their shortcomings within the 2019-2020 range.
New pharmacological targets have been explored in the past years, allowing a broader therapeutic arsenal against biofilm-related pathologies. The Quorum Sensing system was targeted as well in order to avoid the development of intrinsically antibiotic-resistant bacteria and to enhance a proper host defense.
生物膜是一种由微生物组成的复杂聚集物，其特征是存在动态的、粘性的和保护性的细胞外基质，由多糖、蛋白质和核酸组成。据估计，绝大多数人类感染都与微生物所在的生物膜有关，微生物通过群体感应相互交流，从而在恶劣的环境条件下生存。
本篇综述全面关注有前景的抗生物膜生成和清除策略的发展状况，描述了化学结构、结果、给药途径、药物成分和 SAR，以及它们在 2019-2020 年期间的不足之处。
在过去几年中，已经探索了新的药理学靶点，从而为对抗与生物膜相关的病理提供了更广泛的治疗武器。群体感应系统也成为了靶向目标，以避免产生固有抗药性的细菌，并增强适当的宿主防御。
