Fox P T, Burton H, Raichle M E
J Neurosurg. 1987 Jul;67(1):34-43. doi: 10.3171/jns.1987.67.1.0034.
Positron emission tomography measurements of regional cerebral blood flow were used to detect focal neuronal activation in the first somatosensory cortex (SI) of humans induced by cutaneous vibratory stimulation. Intravenously administered water labeled with oxygen-15 (H2(15)O) was used as a blood flow tracer to obtain five stimulated-state and two resting-state blood flow images in each of eight normal volunteers. Three cutaneous surfaces were tested: lips, fingers, and toes. Intense, highly focal SI responses were seen during all 39 stimulated-state trials. The SI responses from the three stimulation sites were anatomically distinct and formed a medial-to-lateral homonculus in every subject. Response magnitudes (increase in local blood flow) and response locales (expressed as proportionately measured bicommissural stereotaxic coordinates) were highly consistent among subjects and on repeated trials for each subject. These findings suggest that eliciting cerebral blood flow responses by cutaneous vibration provides a safe, rapid, and reproducible tool for locating and assessing the functional status of somatosensory cortex, and offers potential clinical and research utility. This study has established normative values for future applications of this experimental paradigm.
正电子发射断层扫描测量局部脑血流量，用于检测皮肤振动刺激诱发的人类第一体感皮层（SI）的局灶性神经元激活。静脉注射用氧-15标记的水（H2(15)O）作为血流示踪剂，在8名正常志愿者中，每人获取5张刺激状态和2张静息状态的血流图像。测试了三个皮肤表面：嘴唇、手指和脚趾。在所有39次刺激状态试验中均观察到强烈、高度局灶性的SI反应。来自三个刺激部位的SI反应在解剖学上是不同的，并且在每个受试者中形成了从内侧到外侧的小人像。反应幅度（局部血流量增加）和反应部位（表示为按比例测量的双连合立体定向坐标）在受试者之间以及每个受试者的重复试验中高度一致。这些发现表明，通过皮肤振动诱发脑血流反应为定位和评估体感皮层的功能状态提供了一种安全、快速且可重复的工具，并具有潜在的临床和研究用途。本研究为该实验范式的未来应用建立了规范值。
