Stoffels I, Alt C, Bekeschus S, Klode J
Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.
Leibniz-Institut für Plasmaforschung und Technologie e. V. (INP Greifswald), ZIK Plasmatis, Greifswald, Deutschland.
Hautarzt. 2020 Nov;71(11):843-849. doi: 10.1007/s00105-020-04691-3.
The socioeconomic significance of chronic venous leg ulcers is considerable due to the high number of patients, the costs of diagnosis and therapy, the deterioration in quality of life, and the loss of working capacity during the disease. This is further increased by a progressive course and an increased tendency to recurrence. Taking these facts into account, surgical treatment options are of particular importance, especially in otherwise therapy-refractory courses. For this purpose, an extensive spectrum of surgical and new, partly not yet finally evaluated, invasive techniques are now available. Venous surgery and endovenous closure techniques are suitable for eliminating primary or secondary varicosis as a causal therapy for venous leg ulcers. Shave therapy is the method of choice in the presence of dermatolipo(fascio)sclerosis. Current long-term results show good results with cure rates of 70-80%. In individual cases, surgical techniques involving fascia cruris (faciotomy, fasciotomy) can also be used. Recurrence ulcers can often be successfully treated by repeated shave therapy, optionally with simultaneous vacuum-assisted dressing techniques or by a fasciotomy. In addition, local invasive techniques such as autologous fat tissue transplantation or autologous platelet-rich plasma can be used to promote wound healing. Thus, both surgically invasive local therapy and advanced surgery of the causes of chronic venous leg ulcers play a key role in the overall therapy concept.
由于患者数量众多、诊断和治疗费用高昂、生活质量下降以及患病期间工作能力丧失,下肢慢性静脉溃疡具有相当大的社会经济意义。疾病的进展过程和复发倾向增加进一步加剧了这种情况。考虑到这些因素,手术治疗方案尤为重要,特别是在其他治疗方法难以奏效的病程中。为此,目前有广泛的手术及新的、部分尚未最终评估的侵入性技术可供选择。静脉手术和静脉内闭合技术适用于消除原发性或继发性静脉曲张,作为下肢静脉溃疡的病因治疗。在存在皮肤脂肪(筋膜)硬化的情况下,削痂疗法是首选方法。目前的长期结果显示效果良好,治愈率为70%-80%。在个别情况下,也可采用涉及小腿筋膜的手术技术(筋膜切开术)。复发性溃疡通常可通过重复削痂疗法成功治疗,可选择同时采用真空辅助包扎技术或筋膜切开术。此外,局部侵入性技术,如自体脂肪组织移植或自体富血小板血浆,可用于促进伤口愈合。因此,手术侵入性局部治疗和慢性下肢静脉溃疡病因的先进手术在整体治疗理念中都起着关键作用。