Dhiman Manoj, Kumawat Aakash Kumar
Department of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Department of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Comput Biol Med. 2020 Nov;126:104007. doi: 10.1016/j.compbiomed.2020.104007. Epub 2020 Sep 16.
To analyse the feasibility of directional ablation using a multi-tine electrode.
A multi-tine electrode capable of operating in multipolar mode has been used to study the directional ablation. In addition to the basic design, similar to commercially available FDA approved multi-tine electrode, tines have been insulated from each other inside the probe base and tip using a thin insulating material of thickness 0.25 mm. A cylindrical single-compartment model of size 6 cm × 6 cm has been used to model normal liver tissue. The temperature-controlled radiofrequency ablation has been employed to maintain the tine-tips at different temperatures. Electro-thermal simulations have been performed by using a commercial multi-physics software package based on finite element methods. To make this study feasible a new approach to predict the ablations have been proposed and used in this study.
Asymmetric ablation zone with up to 5 mm difference in ablation boundary between the intended and non-intended direction has been observed along the transverse direction. Reduction in ablation up to 5 mm along the axial direction in comparison to the monopolar mode has also been observed.
Multi-tine electrode modified to operate in multipolar mode can create directional ablations of different shapes and can be used to target position and shape specific tumours.
分析使用多叉电极进行定向消融的可行性。
采用一种能够在多极模式下运行的多叉电极来研究定向消融。除了基本设计与经美国食品药品监督管理局（FDA）批准的市售多叉电极相似外，电极叉在探头基座和尖端内部使用厚度为0.25毫米的薄绝缘材料相互绝缘。使用尺寸为6厘米×6厘米的圆柱形单室模型来模拟正常肝组织。采用温度控制的射频消融来使电极叉尖端保持在不同温度。通过使用基于有限元方法的商业多物理场软件包进行电热模拟。为使本研究可行，提出并在本研究中使用了一种预测消融的新方法。
沿横向观察到不对称消融区，预期方向和非预期方向之间的消融边界差异高达5毫米。与单极模式相比，沿轴向消融减少了5毫米。
经改进可在多极模式下运行的多叉电极能够产生不同形状的定向消融，可用于靶向定位和形状特定的肿瘤。
