Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands.
Department of Internal Medicine, Antonius Hospital Sneek, Sneek, 8601 ZK, the Netherlands.
J Sport Health Sci. 2022 Mar;11(2):260-265. doi: 10.1016/j.jshs.2020.09.007. Epub 2020 Sep 26.
Physical activity (PA) has substantial health benefits and is important in combatting chronic diseases, which have been associated with elevated levels of advanced glycation endproducts (AGEs). AGEs play a role in the aging process, and an association between PA and AGEs has been reported. We aimed to investigate the relationship between PA and AGE accumulation in a general population and in a population with chronic diseases.
This large cross-sectional population study used data from adult participants in the LifeLines project, with participant information drawn from the LifeLines database as well data from patients with diabetes mellitus or renal and/or cardiovascular diseases. Tissue AGE accumulation was assessed non-invasively by skin-autofluorescence (SAF) using an AGE reader (DiagnOptics Technologies BV, Groningen, the Netherlands). PA was assessed using the short questionnaire to assess health-enhancing physical activity (SQUASH). Multivariate linear regression analyses were adjusted for age, body mass index, sex, and smoking status.
Data from 63,452 participants (general population n = 59,177, chronic disease n = 4275) were analyzed. The general population was significantly younger (43.58 ± 11.77 years, mean ± SD) and had significantly lower SAF (1.90 ± 0.42 arbitrary units (AU)) compared to the population with chronic disease (age: 55.51 ± 12.07 years; SAF: 2.27 ± 0.51 AU). In the group with chronic disease, more hours of moderate to vigorous physical activities per week were associated with lower SAF (β = -0.002, 95% confidence interval (95%CI): -0.002 to -0.001). For the general population, there was no association between hours of moderate to vigorous activity and SAF (β = 3.2 × 10, 95%CI: 0.000-0.001, p = 0.742). However, there was an association in the general population between total hours of PA per week and SAF (β = 4.2 × 10, 95%CI: 0.000-0.001, p < 0.001), but this association was not found in the chronic disease population (β = -3.2 × 10, 95%CI: -0.001 to 0.000, p = 0.347).
Our study demonstrates that an inverse relationship exists between PA and AGE accumulation in the population with chronic disease. More hours of moderate to vigorous activity is associated with a significantly decreased SAF. More PA is associated with a lower SAF, even after adjusting for the established predictors (age, body mass index, smoking status, and sex). Our findings could help to promote health and prolong longevity.
身体活动（PA）对健康有很大的益处，对于对抗慢性病尤其重要，因为慢性病与高水平的晚期糖基化终产物（AGEs）有关。AGEs 在衰老过程中起作用，并且已经报道了 PA 与 AGEs 之间的关联。我们旨在研究一般人群和患有慢性病人群中 PA 与 AGE 积累之间的关系。
这项大型横断面人群研究使用了来自 LifeLines 项目的成年参与者的数据，参与者信息来自 LifeLines 数据库以及患有糖尿病、肾脏和/或心血管疾病的患者的数据。使用 AGE 阅读器（荷兰格罗宁根的 DiagnOptics Technologies BV）通过皮肤自发荧光（SAF）非侵入性地评估 AGE 积累。使用简短的评估健康促进体力活动（SQUASH）问卷评估 PA。多变量线性回归分析调整了年龄、体重指数、性别和吸烟状况。
分析了来自 63452 名参与者（一般人群 n=59177，慢性病 n=4275）的数据。一般人群明显更年轻（43.58±11.77 岁，平均值±标准差）， SAF（1.90±0.42 个任意单位（AU））明显较低，而慢性病患者的 SAF（年龄：55.51±12.07 岁；SAF：2.27±0.51 AU）。在慢性病患者中，每周进行更多小时的中等至剧烈体力活动与较低的 SAF 相关（β=-0.002，95%置信区间（95%CI）：-0.002 至-0.001）。对于一般人群，中等至剧烈活动的小时数与 SAF 之间没有关联（β=3.2×10，95%CI：0.000-0.001，p=0.742）。然而，在一般人群中，每周总 PA 小时数与 SAF 之间存在关联（β=4.2×10，95%CI：0.000-0.001，p<0.001），但在慢性病人群中未发现这种关联（β=-3.2×10，95%CI：-0.001 至 0.000，p=0.347）。
我们的研究表明，在患有慢性病的人群中，PA 与 AGE 积累之间存在反比关系。更多的中等至剧烈活动与 SAF 显著降低相关。更多的 PA 与较低的 SAF 相关，即使在调整了既定的预测因素（年龄、体重指数、吸烟状况和性别）后也是如此。我们的研究结果可能有助于促进健康和延长寿命。
