Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan.
Department Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Int J Clin Pract. 2021 Apr;75(4):e13742. doi: 10.1111/ijcp.13742. Epub 2020 Nov 3.
This study aimed to evaluate the prevalence and predictors of polypharmacy in hospitalised patients in Jordan to help guide healthcare efforts in decreasing the burden on the healthcare system.
This cross-sectional study was conducted at the University of Jordan Hospital in Amman, Jordan. During the study period, a convenience sample of patients admitted to the internal medicine and surgical wards were approached to take part in this study. Following patients' recruitments, patients were interviewed and their medical files were reviewed to obtain demographic and clinical information regarding their medical conditions and their regular use of medicines. Then, the prevelence of patients with polypharmacy were identified, and factors predicting polypharmacy among them were determined.
Among the 300 participants who agreed to participate in this study, females represented 45.3% of the recruited sample (n = 139), and around 48.0% (n = 144) of the study sample were elderly people (≥65 years old). Most of the recruited patients (n = 248, 82.7%) were found to use polypharmacy (≥ 5 medications). Hypertension was the most frequent medical condition among study participants (n = 240, 80.0%) followed by diabetes (n = 185, 61.7%). Results of logistic regression analysis showed that polypharmacy was only significantly affected by patients' age (OR = 2.149, P-value = .024) and monthly income (OR = 0.336, P-value = .009), while other factors were not associated with polypharmacy. Elderly patients (≥65 years) were found to have polypharmacy more significantly than non-elderly patients. Also, those with lower monthly income (<500 JD) were found to use lower polypharmacy compared with those with higher monthly income (>500 JD).
The present study showed that polypharmacy is prevalent among patients in Jordan. While polypharmacy was not affected by smoking status, gender, BMI and educational level, it was significantly affected by monthly income and age. Further plans should be put in place to reduce polypharmacy, starting with effective pharmaceutical care services leading to treatment optimisation and ensuring desired treatment outcomes.
本研究旨在评估约旦住院患者中同时使用多种药物的流行情况和预测因素，以帮助指导减少医疗系统负担的医疗保健工作。
这是一项在约旦安曼的约旦大学医院进行的横断面研究。在研究期间，对内科和外科病房的住院患者进行了方便抽样，邀请他们参与这项研究。在患者招募后，对他们进行了访谈，并查阅了他们的病历，以获取有关他们的医疗状况和常用药物的人口统计学和临床信息。然后，确定同时使用多种药物的患者的流行情况，并确定预测他们同时使用多种药物的因素。
在同意参与这项研究的 300 名参与者中，女性占招募样本的 45.3%（n=139），研究样本中约 48.0%（n=144）为老年人（≥65 岁）。大多数被招募的患者（n=248，82.7%）使用了多种药物（≥5 种药物）。研究参与者中最常见的医疗状况是高血压（n=240，80.0%），其次是糖尿病（n=185，61.7%）。逻辑回归分析结果显示，同时使用多种药物仅受患者年龄（OR=2.149，P 值=0.024）和月收入（OR=0.336，P 值=0.009）的显著影响，而其他因素与同时使用多种药物无关。与非老年人相比，老年人（≥65 岁）更有可能同时使用多种药物。此外，与月收入较高（>500 约旦第纳尔）的患者相比，月收入较低（<500 约旦第纳尔）的患者同时使用的药物较少。
本研究表明，同时使用多种药物在约旦患者中很普遍。虽然同时使用多种药物不受吸烟状况、性别、BMI 和教育程度的影响，但它受到月收入和年龄的显著影响。应制定进一步的计划来减少同时使用多种药物，从提供有效的药物治疗服务开始，以优化治疗并确保达到预期的治疗效果。
