调控序列处DNA结构中可能存在的分子制动。
Possible molecular detent in the DNA structure at regulatory sequences.
作者信息
Lu P, Cheung S, Arndt K
机构信息
Department of Chemistry, University of Pennsylvania, Philadelphia 19104.
出版信息
J Biomol Struct Dyn. 1983 Oct;1(2):509-21. doi: 10.1080/07391102.1983.10507458.
Abstract
A common feature that appears in a number of DNA sites where proteins interact is the sequence GTG/CAC. In the lac operator this sequence leads to a region with a higher imino proton exchange rate well below the optical melting temperature. It is suggested that this reflects a structural feature recognized by proteins that bind specific sites on the DNA molecule.
摘要
在许多蛋白质相互作用的DNA位点中出现的一个共同特征是序列GTG/CAC。在乳糖操纵子中，这个序列导致一个区域的亚氨基质子交换速率较高，且远低于光学熔解温度。有人认为，这反映了一种被与DNA分子上特定位点结合的蛋白质所识别的结构特征。
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