Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia.
Institute of Cytology of the Russian Academy of Sciences, 194064 St. Petersburg, Russia.
Genes (Basel). 2020 Sep 27;11(10):1138. doi: 10.3390/genes11101138.
Cell repair machinery is responsible for protecting the genome from endogenous and exogenous effects that induce DNA damage. Mutations that occur in somatic cells lead to dysfunction in certain tissues or organs, while a violation of genomic integrity during the embryonic period often leads to death. A mammalian embryo's ability to respond to damaged DNA and repair it, as well as its sensitivity to specific lesions, is still not well understood. In this review, we combine disparate data on repair processes in the early stages of preimplantation development in mammalian embryos.
细胞修复机制负责保护基因组免受内源性和外源性因素的影响，这些因素会导致 DNA 损伤。体细胞中的突变会导致某些组织或器官功能失调，而胚胎期基因组完整性的破坏往往会导致死亡。哺乳动物胚胎对受损 DNA 的反应和修复能力，以及对特定损伤的敏感性，目前仍不为人知。在这篇综述中，我们结合了哺乳动物胚胎着床前发育早期修复过程的不同数据。
