McGinnis Timothy, Bantis Leonidas E, Madan Rashna, Dandawate Prasad, Kumer Sean, Schmitt Timothy, Paluri Ravi Kumar, Kasi Anup
School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, KS 66160, USA.
J Clin Med. 2020 Sep 25;9(10):3102. doi: 10.3390/jcm9103102.
Pancreatic intraepithelial neoplasms (PanINs) and intraductal papillary mucinous neoplasms (IPMNs) are common pancreatic adenocarcinoma precursor lesions. However, data regarding their respective associations with survival rate and prognosis are lacking. We retrospectively evaluated 72 pancreatic adenocarcinoma tumor resection patients at the University of Kansas Hospital between August 2009 and March 2019. Patients were divided into one of two groups, PanIN or IPMN, based on the results of the surgical pathology report. We compared baseline characteristics, overall survival (OS), and progression free survival (PFS) between the two groups, as well as OS and PFS based on local or distant tumor recurrence for both groups combined. 52 patients had PanINs and 20 patients had IPMNs. Patients who had an IPMN precursor lesion had better median PFS and OS when compared to patients with PanIN precursor lesions. However, the location of tumor recurrence (local or distant) did not show a statistically significant difference in OS.
胰腺上皮内瘤变（PanINs）和导管内乳头状黏液性肿瘤（IPMNs）是常见的胰腺腺癌前驱病变。然而，关于它们各自与生存率和预后的关联的数据尚缺。我们回顾性评估了2009年8月至2019年3月间堪萨斯大学医院的72例接受胰腺腺癌肿瘤切除术的患者。根据手术病理报告结果，将患者分为两组之一，即PanIN组或IPMN组。我们比较了两组之间的基线特征、总生存期（OS）和无进展生存期（PFS），以及两组合并后基于局部或远处肿瘤复发情况的OS和PFS。52例患者有PanINs，20例患者有IPMNs。与有PanIN前驱病变的患者相比，有IPMN前驱病变的患者的中位PFS和OS更好。然而，肿瘤复发的部位（局部或远处）在OS方面未显示出统计学上的显著差异。
